Alexánderson E, Mendoza RG, Adame G, Talayero JA, Sierra C, Cruz P, García-Rojas L, Rodríguez-Valero M, Flores A, Zárate A, Meave A, Arauz A

Language: Spanish
References: 16
Page: 288-294
PDF size: 140.76 Kb.

ABSTRACT

Objectives: To demonstrate that inflammatory atheromatose carotid plaques can be visualized with positron emission tomography with ¹⁸F-fluorodeoxyglucose (¹⁸FDG PET) in symptomatic patients, in order to correlate them with systemic inflammatory markers, such as CRP. Method: Fifteen patients with cerebral ischemia due to atherosclerotic carotid disease were studied. ¹⁸FDG uptake with PET was considered and blood samples were taken for determining high sensibility C reactive protein (HsCRP). Results: The mean age of the patients was 66 years; 11 of them were males (73%) and 4 were females (27%). ¹⁸FDG PET was positive in 12 patients (80%), while 100% of the studied population had low risk HsCRP with normal white cell count. Conclusions: ¹⁸FDG PET proves active inflammation in carotid atheromatose plaques. There was no significant correlation between the presence of ahteromatose carotid plaques, HsCRP serum levels, and ¹⁸FDG PET study.

REFERENCES

1. Ross R: Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-26.

2. Pearson T, Mensah G, Alexander W: Markes of inflammation and Cardiovascular Disease. Circulation 2003; 28: 499-510.

3. Rudd J, Warburton E, Fryer T, et al: Imaging Atherosclerotic Plaque Inflammation with [18F]-fluorodeoxyglucose Positron Emission Tomography. Circulation 2002; 11:2708-11.

4. Adams HP Jr, Bendixen BH, Kapelle LJ, et al: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: TOAST: trial of ORG 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.

5. Van den Mee I, De Mat M, Hak E, et al: C-Reactive Protein predicts progression of atherosclerosis measured at various sites in the arterial tree. The Rotterdam Stroke 2002; 33: 2750-55.

6. Lederman RJ, Raylman RR, Fisher SJ, et al: Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nuc Med Commun. 2001; 22: 747-53.

7. Davies JR, Rudd JH, Weissberg PL: Molecular and Metabolic Imaging of Atherosclerosis. J Nucl Med 2004; 45(11): 1898-1907.

8. Tahara N, Kai H, Yamagishi S, Mizoguchi M, Nakaura H, Ïshibashi M, et al: Vascular inflammation evaluated by 18F-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 2007; 49(14): 1533-39.

9. Ogawa M. Ishino S, Mukai T, et al: 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 2004; 45(7): 1245-50.

10. Straus HW, Dunphy M, Tokita N: Imaging the vulnerable plaque: A Scintillating light at the end of the Tunnel. J Nucl Med 2004; 45(7): 1106-07.

11. Tawakol A, Migrino R, Bashian G, Bedri S, Vermylen D, Cury R, et al: In vivo 18F-Fluorodeoxyglucose Positron Emission Tomography imaging provides a non invasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol, 2006; 48(9): 1818-24.

12. Tatsumi M, Cohade C, Nakamoto Y, Wahl RL: Fluorodeoxyglucose uptake in the aortic wall at PET/CT: possible finding for active atherosclerosis. Radiology 2003; 229(3): 831-37.

13. El-Haddad G, Alavi A, Mavi A: Normal variants in [18F]-fluorodeoxyglucose PET imaging. Radiol Clin N Am 2004; 42: 1063-81.

14. Alexanderson E, Soto ME, Ricalde A, Meave A, Reyes P: Inflammatory activity in Takayasu arteritis detection through positron emission tomography. Arch Cardiol Mex 2005; 75(1): 82-5.

15. Nan B, Yang H, Yan S, Lin PH, Lumstden AB, Yao Q, et al: C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005; 138(2): 212-22.

16. Yamaji K, Wang Y, Liu Y, Abeyama K, Hashiguchi T, Uchimura T, et al: Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation. Thromb Res 2005; 115(4): 319-25.