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Anales Médicos de la Asociación Médica del Centro Médico ABC

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Revista de la Asociación Médica del Centro Médico ABC
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2004, Number 1

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An Med Asoc Med Hosp ABC 2004; 49 (1)

Cushing’s syndrome secondary to the topical use of steroids

Antillón FCA, Faugier FE, Gómez RD
Full text How to cite this article

Language: Spanish
References: 6
Page: 43-46
PDF size: 71.49 Kb.


Key words:

Cushing’s syndrome, glucocorticoids, cortisol, betametasona.

ABSTRACT

Female infant, with previous external application of betametasona, for eight months, with clinical and laboratory features of Cushing’s sindrome: growth failure, hyrsutism, generalized dermatosis, hypotrophic extremities, centripetal obesity, with most fat accumulation in the face and neck, premature pubarche. Cushing’s syndrome is the clinical consequence of a high concentration of plasma cortisol. In this case, topic was indiscriminately applied. We gradually reduced the glucocorticoid dose, until it was possible to avoid complications by the suppression of the hypothalamic-pituitary-adrenal axis that the patient presented. Recovery iniciated after weeks. The use of glucocorticoids, regardless of the administration route, should be under strict medical vigilance.


REFERENCES

  1. Diez JJ. Tratamiento farmacológico del síndrome de Cushing. Rev Cub Med 1999; 38 (1): 35–66.

  2. Findling JW, Tyrrel JB. Ocult ectopic secretion of corticotropin. Arch Inter Med 1986; 146: 929–933.

  3. Sperling, M. Cushing’s syndrome. Pediatric endocrinology, Philadelphia, PA: WB Saunders, 1996, 296–301.

  4. Magiakov MA, Mastorakos G, Oldfield EH et al. Cushing’s syndrome in children and adolescents: Presentation, diagnosis and therapy. N Engl J Med 1999; 331: 629.

  5. Lee PA, Weldon VV, Migean CJ. Short stature as the only clinical sign of Cushing’s syndrome. J Pediat 1975; 86: 89.

  6. Mc Arthur RG, Cloutier MD, Hayles AB, Sprague RE. Cushing’s disease in children: Findings in 13 cases. Mayo Clinic Proc 1972; 47: 318.




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An Med Asoc Med Hosp ABC. 2004;49