2004, Number 2
Effects and behaviour of polidisperse macromolecules in low pressure pulmonary edema secondary oleic acid infusion
Palomar A, Oppenheimer L
Full text
Language: Spanish
References: 8
Page: 79-91
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ABSTRACT
Previously in low-pressure pulmonary edema (LPPE) induced with oleic acid (OA) in isolated lobes, we achieved edema reabsorption with 6% Hetastarch (HTS) a colloidal plasma expander.1,2 In this study, this approach was tested in intact animals. Severe LPPE was produced in 19 dogs with intravenous OA (0.075 mg/kg). Two hours later, dogs were randomized into a control (n = 9) and a treatment group (n = 10). In the treatment group, HTS was infused to maintain oncotic pressures (COP) at COP > 30 mmHg. This required ultra filtration of excess fluid to sustain pulmonary wedge pressure (PWP) at baseline levels. To control for the effects of ultrafiltration, non-treated HTS dogs (controls) were infused normal saline and were ultrafiltered to maintain comparable PWP. In the HTS treated animals, COP rose to 34.7 ± 10, compared to 5.1 ± 3.2 mmHg in controls. There were no differences in PWP. Although significant HTS extravasations occurred suggested by dry weight of treated lungs 2.84 ± 0.29 compared to controls 2.33 ± 0.3 g/kg.dog.weight, (p < 0.05), edema was significantly improved in HTS treated animals, as deduced from a significant reduction in pulmonary wet weight 24.9 ± 5.8 g/kg dog weight in comparison with control group 34.3 ± 11.8 (p < 0.05). The administration of HTS reduced the edema formation in severe LPPE secondary to OA but not enough to significantly improve gas exchange.REFERENCES
Palomar A, Fernández R, Gómez A, Oppenheimer L, et al. Effect of moderate level of superimposed alveolar hypoxia on the rate of edema formation and proteins transport in a canine isolated lobe model of hydrostatic pulmonary edema, using spectrophotometric methods. Neumología y Cirugía de Tórax 2003; 62(1): 6-14.