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NCT Neumología y Cirugía de Tórax

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Antes Revista del Instituto Nacional de Enfermedades Respiratorias

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2004, Number 2

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Neumol Cir Torax 2004; 63 (2)

S. pneumonia resistance: Main obstacle in the management of Community Acquired Pneumonia

Acuña-Kaldman M
Full text How to cite this article

Language: Spanish
References: 10
Page: 96-101
PDF size: 67.67 Kb.


Key words:

Pneumonia, S. pneumoniae, bacterial resistance..

ABSTRACT

Lower respiratory tract infections still cause high morbidity and mortality rates in the world. In 1998, the WHO reported more than 3.7 million deaths caused by these infections worldwide. Finishing Second World War, in the middle of twenty century, the first anti-microbial agents were developed showing healing capacity for this kind of infections, making us think that lower respiratory tract infections would be history in the years ahead and may be for good, thanks to penicillin and the rest of new antimicrobial agents. Unfortunately six decades after the development of penicillin we find that the epidemiological burden of lower respiratory tract infections is still at large, causing a very huge impact on time, economical resources and human lives. The reason behind this permanence of the problem resides in bacterial resistance, which has arised and made obsolete many antimicrobial agents through the world. The present paper analyzes the current situation regarding the resistance and susceptibility profiles of S. pneumoniae, as long as this is the main pathogen involved in the development of the so called community acquired pneumonia, or CAP.


REFERENCES

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  2. Castanheira M, Gales AC, et al. Antimicrobial susceptibility of S. pneumoniae in Latin America: results from 5 years of the SENTRY Antimicrobial Surveillance Program. Clin Microbiol Infect. 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.

  3. Quiñones FF, Calva JJ, et al. Antimicrobial susceptibility patterns of S. pneumoniae in Mexico. Diagnostic Microbiology and Infectious Disease 2004; 49: 53-58.

  4. Tice AD. Community-Acquired Pneumonia: Recent Insights into an Old Disease. Infect Med 20(7): 352-356, 2003.© 2003 Cliggot Publishing. Division of SCP Communications.

  5. Lode H, Aronkyto T, et al. A randomized, double-blind, double-dummy comparative study of gatifloxacin with clarithromycin in the treatment of community-acquired pneumonia. Clin Microbiol Infect 2004; 10: 403-408.

  6. Guidelines for the Management of adults with community-acquired pneumonia. American Thoracic Society. Am J Respir Crit Care Med 2001; 163: 1730-1754.

  7. Spratt BG. Resistance to antibiotics mediated by target alterations. Science 1994; 264(5157): 388-93.

  8. Figuereido AM, Austrian R, et al. Novel penicillin-resistant clones of Streptococcus pneumoniae in the Czech Republic and in Slovakia. Microb Drug Resist Spring 1 (1):71-8

  9. Felmingham D. Comparative antimicrobial susceptibility of respiratory tract pathogens. Chemotherapy 2004; 50 Suppl 1: 3-10.

  10. Daly MM, et al. Characterization and prevalence of MefA, MefE and the associated msr(D) gene in Streptococcus pneumoniae Clinical Isolates. J Clin Microbiol 2004; 42(8): 3570-4.




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Neumol Cir Torax. 2004;63