Rubio-Donnadieu F

Language: Spanish
References: 8
Page: 409-411
PDF size: 54.98 Kb.

ABSTRACT

Nitric oxide (NO) is considered as a non-conventional messenger that does not accumulate in the presynaptic vesicles, is not released by means of exocytosis, and has no specific post-synaptic receptors. NO, a gas with a half-life of seconds may have a dual effect during both brain ischemia and epileptic discharges. The mechanisms of neuroprotection, angiogenesis and possible neurogenesis are reviewed, as well as the involvement of NO as a free radical during the epileptic phenomenon, which affects neuronal membranes and gene expression, considered the main cause of temporal lobe mesial sclerosis, responsible for more than 50% of epileptic seizures. Finally, the possible antiepileptic actions of NO associated with drugs such as valproate, etosuccimide and carbamazepine are addressed.

REFERENCES

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