Gaceta Médica de México

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Gaceta Médica de México >Year 2007, Issue 6

Miguel-Pérez P, Herrera-Hernández M, Padilla-Rodríguez A, Martínez-Consuegra N
Adenoma oncocítico de tiroides (adenoma de células de Hürthle). Revisión del espectro morfológico a propósito de cuatro casos
Gac Med Mex 2007; 143 (6)

Language: Español
References: 32
Page: 517-522
PDF: 201.72 Kb.

Full text


Oncocytic change involves a cytoplasmic enlargement due to mitochondrial accumulation observed in a wide variety of conditions and in multiple organs. It can be reactive or neoplastic. In the thyroid gland, this change is a metaplastic phenomenon that takes place under different circumstances that promote cellular stress, and could even produce a true neoplasm, both benign or malignant. The oncocytic adenoma, a malignant tumor will be described. We analyzed four cases studied at the surgical pathology department of the American British Cowdray Medical Center in Mexico City that displayed unusual cytomorphological features. They became a diagnostic challenge and in order to solve it we reviewed their morphological spectrum. Tumor characteristics in all cases included: massive ischemic necrosis short after a fine needle aspiration biopsy was performed, unexpected large size, coexistence with a malignant independent neoplasm and cytological features similar to those observed in papillary carcinomas. It is of utmost importance for the pathologist to acknowledge the existence of these features in order to avoid diagnostic mistakes that could lead to unsuccessful treatment.

Key words: Oncocytic adenoma, thiroyd.


  1. Rosai J, Carcangiu ML, Delellis RA. Tumours with oncocytic features. En: Rosai J, Carcangiu ML, Delellis RA, editors. Atlas of tumor pathology. Tumors of the thyroid gland. US: Armed Forces Institute of Pathology; 1990. pp. 161-181.

  2. Asa SL. My approach to oncocytic tumours of the thyroid. J Clin Pathol 2004;57:225-232.

  3. Giangaspero F, Cenacchi G. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Semin Diagn Pathol 1999;16:91-97.

  4. Papotti M, Cassoni P, Taraglio S, Bussolati G. Oncocytic and oncocytoid tumors of the exocrine pancreas, liver, and gastrointestinal tract. Semin Diagn Pathol 1999;16:126-134.

  5. Ritter JH, Nappi O. Oxyphilic proliferations of the respiratory tract and paranasal sinuses. Semin Diagn Pathol 1999;16:105-116.

  6. Paulino AF, Huvos AG. Oncocytic and oncocytoid tumors of the salivary glands. Semin Diagn Pathol 1999;16:98-104.

  7. Young RH, Scully RE. Oxyphilic tumors of the female and male genital tracts. Semin Diagn Pathol 1999;16:146-161.

  8. Suster S. Tumors of the skin composed of large cells with abundant eosinophilic cytoplasm. Semin Diagn Pathol 1999;16:162-177.

  9. Damiani S, Dina R, Eusebi V. Eosinophilic and granular cell tumors of the breast. Semin Diagn Pathol 1999;16:117-125.

  10. D´amore ES, Ninfo V. Tumors of the soft tissues composed of large eosinophilic cells. Semin Diagn Pathol 1999;16:178-189.

  11. Reuter EV. Renal tumors exhibiting granular cytoplasm. Semin Diagn Pathol 1999; 16:135-145.

  12. Cristofaro MG, Vescio G, Fava MG, Aversa C, Amantea M, Giudice M. Hürthle cell neoplasm: our experience. Ann Ital Chir 2004;75:663-668.

  13. Cannizzaro M, Fiorenza G, Garofalo L, De Maria A, Cavallaro N, Pulvirenti A,et al. Hürthle cell thyroid neoplasms: a clinical enigma. Ann Ital Chir1999;70: 503-508.

  14. Nappi O, Ferrara G, Wick MR. Neoplasms composed of eosinophilic polygonal cells: an overview with consideration of different cytomorphologic patterns. Semin Diagn Pathol 1999;16:82-90.

  15. Nesland JM, Sobrinho-Simoes MA,Holm R,Sambade MC,Johannessen JV. Hürthle cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry. Ultrastruct Pathol 1985;8:269-290.

  16. Hedinger CE, Williams ED, Sobin LH. Histological typing of thyroid tumours. En: Hedinger CE, editor. International histological classification of tumours. Vol. 11. 2a edition. Berlin: Springer-Verlag; 1988.

  17. De Lellis RA, Lloid RV, Heitz PU, Eng C. Pathology and genetics of tumours of endocrine organs. Lyon: World Health Organization Classification of Tumours/ IARC Press; 2004. pp. 49-133.

  18. Janser JC, Pusel J,Rodier JF, Navarrete E, Rodier D. Hürthle cell tumor of the thyroid gland. Analysis of a series of 33 cases. J Chir 1989;126:619-624.

  19. Gordon DL, Flisak M, Fisher SG. Changes in thyroid nodule volume caused by fine-needle aspiration: a factor complicating the interpretation of the effect of thyrotropin supression on nodule size. J Clin Endocrinol Metab 1999;84:4566- 4569.

  20. Gordon DL, Gatuso P, Castelli M, Bayer W, Emmanuelle MA, Brooks MH. Effect of fine needle aspiration biopsy on the histology of thyroid neoplasms. Acta Cytol 1993;37:651-654.

  21. Raikhlin NT, Smirnova EA, Pavlovskaia AI, Rotin DL, Gurevich LE, Savelov NA. Askenazi (Hürthle) cell tumors of the thyroid. Arch Patol 2005;67:13-16.

  22. Mai KT, Elmontaser G, Perkins DG, Thomas J, Stinson WA. Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. Int J Surg Pathol 2005;31:37-41.

  23. Blumenfeld W, Nair R, Mir R. Diagnostic significance of papillary structures and intranuclear inclusions in Hürhle cell neoplasms of the thyroid. Diagn Cytopathol 1999;20:185-189.

  24. Herrera MF, Hay ID, WU PS, Goellner JR, Ryan JJ, Ebersol JR, et al. Hürtle cell (oxyphilic) papillary thyroid carcinoma: a variant with more aggressive biologic behavior. World J Surg 1992;16:669-675.

  25. Beckner ME, Heffess CS, Oertel JE. Oxyphilic papillary thyroid carcinoma. Am J Clin Pathol 1995;103:280-287.

  26. Pisanu A, Sias L, Uchhedu A. Factors predicting malignancy of Hürthle cell tumors of the thyroid: influence on surgical treatment. World J Surg 2004;28:761-765.

  27. Sack M, Astengo-Osuna C, Lin BT, Battifora H. HBME-1 immunostaining in thyroid fine-needle aspirations: a useful marker in the diagnosis of carcinoma. Mod Pathol 1997;10:668-674.

  28. Xing M, Vasko V, Tallini G, Larin A, Wu G, Udelsman R, et al. BRAFT T1796 A transversion mutation in various thyroid neoplasms. J Clin Endocrinol Metab 2004;89:1365-1368.

  29. Russo F,Barone Adesi TL, Di Lorenzo N, Sica GS, Spina C, Sileri P, et al. Hürthle cell neoplasms of the thyroid gland. G Chir 1998;19:103-108.

  30. Mirebeau-Prunier D. Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma. Eur J Endocrinol 2004;150: 269-276.

  31. Ozlem Kucuk N, Kulak H, Tokmak E, Tar P, Ibis E, Aras G. Hürthle cell carcinoma: a clinicopathological study of thirteen cases. Nucl Med Commun 2006;27:377-379.

  32. Melck A, Bugis S, Baliski C, Irvine R, Anderson DW, Wilkins G, et al. Hemithyroidectomy: The preferred initial surgical approach for management of Hürthle cell neoplasm. Am J Surg 2006;191:593-597.

>Journals >Gaceta Médica de México >Year 2007, Issue 6

· Journal Index 
· Links 

Copyright 2019