2008, Number 1
Risk of terminal ileum anastomosis dehiscence in Rex albino rabbits treated with a norepinephrine infusion
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ABSTRACTObjective: To determine the risk for dehiscence of an intestinal anastomosis with decreased splanchnic flow by means of norepinephrine infusion.
Setting: Third level health care center.
Design: Prospective, experimental, comparative study.
Statistical analysis: Chi square test and relative risk assessment.
Material and methods: The study was performed in 34 Rex albino rabbits, divided in two groups of 17 rabbits each. All rabbits were subjected to laparotomy performing a complete section and anastomosis of the terminal ileum. Experimental rabbits were maintained with a norepinephrine flow of 0.4 mg/kg/min during the first 12 h after surgery; the other group corresponded to the control group.
Results: Both groups were similar in terms of age, sex, and weight. All rabbits treated with norepinephrine presented dehiscence of the anastomosis (100%), whereas in the control group only one rabbit (5.8%) presented it; statistical analysis between both groups revealed a significant difference (p ‹ 0.001). The rabbits subjected to the norepinephrine flow presented an 18-fold higher risk (RR = 18.0, IC 95% 2.6-120.9) than the control group to develop dehiscence of the intestinal anastomosis.
Conclusions: The risk of dehiscence of intestinal anastomosis performed in Rex albino rabbits increases significantly when using norepinephrine.
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