Calderón ANL, García ERM, Paasch MLH

Language: English/Spanish
References: 8
Page: 21-24
PDF size: 221.89 Kb.

ABSTRACT

In order to establish an animal model for the study of the pathogenesis of acute haemorrhagic diathesis, intrinsic and extrinsic pathways of coagulation were evaluated and blood cell counts were determined with special emphasis on platelet counts on 16 experimentally infected pigs with Classical Swine Fever virus and on four non infected controls. In the present study no coagulation disorders could be detected, however, there was a significant reduction in platelet counts detectable after the third day postinfection. Thrombocythopenia as a probable cause of disseminated haemorrhages is discussed. This disorder is attributed to a direct viral effect on platelest and/or its precursors and is independent of platelet aggregation in diseminated intravascular coagulation.

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