Alexánderson RE

Language: Spanish
References: 8
Page: 163-165
PDF size: 84.45 Kb.

ABSTRACT

Positron emission tomography (PET), in its synchronized mode, also known as Gated-PET, is a powerful diagnostic tool in ischemic cardiopathy. This technique allows adding information regarding cardiovascular system functionality to traditionally PET-generated data on myocardial perfusion and endothelial function. With the aid of radiopharmaceuticals such as nitrogen-13 (¹³N) and 82-rubidium (⁸²Rb), both with ultra-short half-lives, it’s possible to perform a myocardial dynamic evaluation. Recently, our group has begun the first protocol ever in Latin America to include Gated-PET. From a group of 20 patients, in 14 of them (70%), it was possible to diagnose myocardial ischemia. In 13 from those patients, a significant decrease in the left ventricular ejection fraction (LVEF) during pharmacological onset with adenosine, was observed. In 6 patients (30%), myocardial ischemia was undiagnosed. After the analysis of Gated-PET data, we found that in 5 of them, LVEF was increased during pharmacological onset with adenosine. In healthy subjects, normal behavior consists of a LVEF increase in order to compensate body metabolic demands.

REFERENCES

1. Di Carli MF: Advances in Positron Emission Tomography. J Nucl Cardiol 2004; 11: 719-32.

2. Alexánderson E, Gómez-Matín D, Fermon S y Meave A: Correlación entre la fracción de expulsión obtenida con SPECT sincronizado y la ventriculografía con radionúclidos en pacientes con cardiopatía isquémica. Arch Cardiol Mex 2004; 74: 25-30.

3. Di Carli MF, Dorbala S, Hachamovithc R: Integrated Cardiac PET-CT for the diagnosis and management of CAD. J Nucl Cardiol 2006; 13: 139-44.

4. Schelbert H, Henze E: Positron Emission Tomography of the Heart. Semin Nucl Med 1980; 10: 355-373.

5. Khorsand A, Graf S, Eidher H, Wadask W, Kletter K, Sochor H, Schuster E, Porenta G: Gated Cardiac 13N-NH3 PET for assessment of left ventricular volumes, mass, and ejection fraction: comparison with electrocardiography-gated 18F-FDG PET. J Nucl Med 2005; 46: 2009-13.

6. Hofman HA, Knaapen P, Boellaard R, Bondarenko O, Gotte MJ, Van Dockum WG, Viesser CA, Van Rossum AC, Lammertsma AA, Visser FC: Measurement of left ventricular volumes and function with O-15-Labeled carbon monoxide gated positron emission tomography: comparison with magnetic resonance imaging. J Nucl Cardiol 2005; 12: 639-44.

7. Schwaiger M, Ziegler S, Nekolla S. PET-CT: Challenge for Nuclear Cardiology. J Nucl Med 2005; 46: 1664-1678.

8. Nekolla S, Souvatzoglou M, Hausleiter J: Integration of function and morphology in cardiac PET/CT: A feasibility study in patients with chronic ischemic heart disease. J Nucl Cardiol 2005: 12: s45.