Augoustides JGT

Language: English
References: 0
Page: 29
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Preconditioning of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. This technique is important for the anesthetist, given that myocardial ischemia is a leading cause of perioperative morbidity and mortality.
The preconditioning stimulus may be ischemic or pharmacologic. An ischemic stimulus may be local (that is, ischemia of the myocardium) or remote (that is, ischemia of a tissue other than the heart). A perioperative pharmacologic stimulus may be inhalational or intravenous. This lecture will discuss (1) local ischmic preconditioning; (2) remote ischemic preconditioning; (3) inhalational preconditioning; (4) intravenous preconditioning; and (5) future directions.