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2004, Number 3

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Rev Inst Nal Enf Resp Mex 2004; 17 (3)

Laryngeal amyloidosis successfully treated with external radiotherapy. Case report.

Durán CM, José Luján CPJ, Sánchez MGA

Language: Spanish
References: 19
Page: 198-203
PDF size: 71.70 Kb.


ABSTRACT

Laryngeal amyloidosis is an uncommon disease accounting for 0.68% of benign tumors of the larynx. It can present as a nodular tumor or diffuse subepithelial deposition forming a mass and causing hoarseness, dysphagia or even airway obstruction. Treatment has historically focused on debridement, laser ablation, stent placement and in some cases colchicine, melphalan and prednisone. We present a case of laryngeal amyloidosis persistent to management with laser ablation and melphalan/prednisone, successfully managed with external beam radiation therapy. Fourteen months after a moderate radiation dose, the patient remained without symptomatic or image data of disease. The literature concerning the role of radiation therapy in the treatment of laryngeal amyloidosis is reviewed.


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