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2004, Number 6

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salud publica mex 2004; 46 (6)

Infant exposure to potentially toxic plasticizers in products for oral use

Bustamante-Montes LP, Lizama-Soberanis B, Vázquez-Moreno F, García-Fábila MM, Corea-Téllez KS, Olaiz-Fernández G, Borja-Aburto VH
Full text How to cite this article

Language: Spanish
References: 19
Page: 501-508
PDF size: 109.28 Kb.


Key words:

phthalate, exposure, polyvinyl chloride (CPV), Mexico.

ABSTRACT

Objective. To estimate the prevalence of oral product use in children less than three years of age, and to measure the concentration of phthalates as potentially toxic products. Material and Methods. In 1999, 199 mothers of children living in the city of Toluca agreed to household interviews. Samples of oral products used by the children were taken and analyzed by gas chromatography to identify and quantify phthalate concentrations, to estimate the daily intake of phthalates from this source. Results. The prevalence of oral product use was 13%. Male infants less than 18 months of age of low socioeconomic level used them more frequently. The concentrations ranged from traces to 67% weight. The mean exposure to products manufactured with polyvinyl chloride and phthalates was 13.94 mg/kg/day (95% CI 9.08,18.89). Conclusions. The daily dose of phthalate intake from products for infants to suck or bite did not exceed the recommended limit established in other countries. Nevertheless, other sources can contribute to increase the total dose. Since some phthalates are harmful to the reproductive system in animals and this potential effect may also be expected in humans, it is necessary to assess other sources and determine exposure using biomarkers.


REFERENCES

  1. National Toxicology Program. (1982a) Carcinogenesis bioassay of di (2etylhexyl)phthalate(CAS No. 103-23-I) in F344 rats and B6C3F1 mice (feed study). Tech. Rep. Ser.212. Research Triangle Park (NC), USA: National toxicology Program; 1982.

  2. National Toxicology Program (NTP) (I 982a) carcinogenesis bioassay of di(2etylhexyl)phthalate(CAS No. 117-81-7) in F344 rats and B6C3FI mice (feed study) Tech. Rep. Ser.217. Research Triangle Park (NC), USA: National Toxicology Program; 1982.

  3. National Toxicology Program, National Institute of Environmental Health Sciences. Final Report on the Reproductive Toxicity of Di(n-Butyl) Phthalate (CAS NO 84-74-2) in Sprague-Dawley Rats. National Technical Information Service (NTIS), U.S. Department of Commerce; Springfield (VA): NTIS Publication NO. 92-1 1 1996.

  4. Harrison PT, Holmes P, Humfrey CD. Reproductive health in humans and widelife: Are adverse trends associated with environmental chemica exposure? Sci Total Environ 1997;205:97-106.

  5. Mylchreest E, Foster PM.Antiandrogenic effects of di(n-Butyl) phthalate on male reproductive development:A nonreceptor-mediated mechanism. CIIT Activities 1998;18:1.10.

  6. Greenpeace. PVC toys and phthalates. England: Greenpeace Press; 1997.

  7. Marín ML, López J, Sánchez A,Vilaplana J, Jiménez A. Analysis of potentially toxic phthalate plasticizers used in toy manufacturing. Bull Environ Contam Toxicol 1998;60:68-73.

  8. Babich MA.The risk of chronic toxicity associated with exposure to disononyl phthalate (DINP) in children's products. Report of U.S. Consumer Product Safety. Washington, DC: CPSC; 1998.

  9. 9.Treybal RE. Operaciones de transferencia de masa. 2° edición. México, DF: Mc Graw Hill; 1988.

  10. Corea Téllez KS. Difusión de ftalatos provenientes de plastificados de policloruro de vinilo (PCV), en agua y saliva (tesis).Toluca, Estado de Mexico: Universidad Autónoma del Estado de México; 2002. II. European Scientific Committee on Toxicity, Ecotoxicity, and the Environment. Opinion on phthalate migration from soft PVC toys and childcare articles. Opinión expressed at the 6`h (CSTEE Plenary Meeting; 1998 nov 26-27; Brussels. Disponible en: http://europa.eu.int/comm/ food/fs/sc/sct/outl9 _en.html [2001 July 3].

  11. Doull J, Cattley R, Elcombe C, Lake BG, Swenberg J,Wilkinson C et al. Cancer risk assessment of Di(2-ethylhexyl) phthalate:Application of the New U.S. EPA Risk Assessment Guidelines. Regul Toxicol Pharmacol 1999;29:327-357.

  12. 13.Thomas JA, Northup SJ.Toxicity and metabolism of monoetylhexyl phthalate and dietylhexyl phthalate:A survey of recent Iiterature.J Toxicol Environ Health 1982;9:141-152.

  13. Foster PMD.Assesing the effects of chemicals on male reproduction: Lessons learnes fron di-n-butyl phthalate. CIIT Activities 1997;17(9):1-8.

  14. Parmar D, Srivastava SP, Singh GB,Seth PK.Testicular toxicity of di(2ethylhexyl) phthalate in developing rats.Vet Hum Toxicol 1995;37: 310-311.

  15. National Toxicology Program, Center for the Evaluation of Risks to Human Reproduction; ntp-cerhr Expert Panel Report on Di(2-ethylhexyl)phthalate. ntp-cerhr-dehp-00. Research Triangle Park (NC): 2000: http://cerhr.niehs.nih.gov/news/DEHP- final.pdf [2001 julio 19]. I7.Tavacova S, Little R, Balavaeva L. Maternal exposure to phthalates and complications of pregnancy. Epidemiology 1999; suppl 10:127.

  16. Hoppin JA, Ulmer R, London SJ. 2004. Phthalate exposure and pulmonary function. Environ Health Perspect: [Online] Disponible en: http://ehp.niehs.nih.gov/docs/2004/6564/abstract.html.

  17. Page BD, Lacroix GM.The occurrence of phthalate ester and di-2 etylhexyl adipate plasticizers in Canadian packaging and food sampled in 1985-89 a survey. Food Addit Contam 1995;12:129-151.

  18. EU Scientific Committee for Toxicity, Ecotoxicity and the Environment (CSTEE). Phthalate migration from soft PVC toys and child-care articles. Opinion expressed at the CSTEE third plenary meeting. 1998 24 April. Brussels. Disponible en: http://europa.eu.int/ comm/health/ph_risk/committees/sct/documents/out45 _en. pdf.

  19. Blount BC, Milgram KE, Silva MJ, Malek NA, Reidy JA, Needham LL et al. Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS. Anal Chem 2000;72:4127-4134.




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salud publica mex. 2004;46