Romero-Velarde E, Campollo-Rivas O, Celis RA, Vásquez-Garibay EM, Castro-Hernández JF, Cruz-Osorio RM

Language: Spanish
References: 25
Page: 103-108
PDF size: 88.33 Kb.

ABSTRACT

Objective. To assess the risk of dislypidemia associated with obesity in children and adolescents. Material and Methods. A cross sectional study was conducted with 62 obese children (BMI › 95 centile and tricipital skinfold thickness › 90 centile) and 70 non-obese children (BMI 5-85 centile) ages 5-15 years, without chronic diseases. Subjects’ characteristics and family background of chronic diseases were collected and a lipid profile was determined. The risk of lipid alterations in the obese children was calculated using odds ratio (OR) and multivariate analysis. Results. Mean age was 9.8 ± 2.7 years in both groups; 63 girls and 69 boys were included. Obesity was associated with abnormal values for cholesterol, triglycerides, LDL, HDL and dislypidemia (› 1 abnormal value) (OR 4.47-15.0). In obese children and adolescents the multivariate analysis showed that female gender was associated with dislypidemia. Conclusion. Obesity in children and adolescents is associated with high risk of dislypidemia; the risk is higher among females.

REFERENCES

1. Troiano RP, Flegal KM. Overweight children and adolescents: Description, epidemiology, and demographics. Pediatrics 1998;101: 497-504.

2. De Onis M, Blössner M. Prevalence and trends of overweight among preschool children in developing countries. Am J Clin Nutr 2000;72:1032-1039.

3. Rivera DJ, Shamah LT, Villalpando HS, González CT, Hernández PB, Sepúlveda J. Encuesta Nacional de Nutrición 1999. Estado nutricio de niños y mujeres en México. Cuernavaca: Instituto Nacional de Salud Pública, 2001.

4. Dietz WH. Health consequences of obesity in youth: Childhood predictors of adult disease. Pediatrics 1998;101 suppl:518-524.

5. Barlow SE, Dietz WH. Obesity evaluation and treatment: expert committee recommendations. Pediatrics 1998;102: e29.

6. Rocchini AP. Childhood obesity and diabetes epidemic. N Engl J Med 2002;346:854-855.

7. Ram W, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Sara E, et al. Obesity and the metabolic sydrome in children and adolescents. N Engl J Med 2004;350:2363-2374.

8. Jessup A, Harrell JS. The metabolic syndrome: Look for it in children and adolescents, too!. Clinical Diabetes 2005;23:26-32.

9. Frisancho RA. Anthropometric standards for the assessment of growth and nutritional status. Ann Arbor: The University of Michigan Press, 1993.

10. Mejía-Aranguré JM, Fajardo-Gutiérrez A, Gómez-Delgado A, Cuevas- Urióstegui ML, Hernández-Hernández DM, Garduño-Espinoza J et al. El tamaño de muestra: un enfoque práctico en la investigación clínica pediátrica. Bol Med Hosp Infant Mex 1995;52:381-391.

11. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: The Bogalusa Heart Study. Pediatrics 1999;6:1175-1182.

12. American Academy of Pediatrics. Committee on Nutrition. Cholesterol in childhood. Pediatrics 1998;101:141-147.

13. National Cholesterol Education Program. Report of the Expert Panel on blood cholesterol levels in children and adolescents. Pediatrics 1992;89 suppl:525-583.

14. World Health Organization. Standarization procedures for the collection of weight and height data in the field. En: World Health Organization. Measuring change in nutritional status. Ginebra: WHO, 1983:41-45.

15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of plasma low density lipoprotein cholesterol concentration without use of the preparative ultracentrafuge. Clin Chem 1972;18:499-502.

16. Speiser WP, Rudolf MC, Anhalt H, Camacho-Hubner C, Chiarelli F, Eliakim A, et al. Consensus statement: Childhood obesity. J Clin Endocrinol Metab 2005;90:1871-1887.

17. Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan ML. The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab 2005;90:4255-4259.

18. Dietz WH. Childhood weight affects adult morbidity and mortality. J Nutr 1998;128:S411-S414.

19. Bellu R, Ortisi MT, Scaglioni S, Agostini C, Salanitri VS, Riva E, et al. Lipid and apolipoprotein A-1 and B levels in obese school-age children: Results of a study in the Milan area. J Pediatr Gastroenterol Nutr 1993;16:446-450.

20. Nain-Feng Chu, Rimm EB, Wang DJ, Liou HS, Shieh SM. Clustering of cardiovascular disease risk factors among obese schoolchildren: The Taipei Children Heart Study. Am J Clin Nutr 1998;67:1141-1146.

21. Forrester TE, Wilks RJ, Bennett FI, Simeon D, Osmond C, Allen M, et al. Fetal growth and cardiovascular risk factors in Jamaican schoolchildren. BMJ 1996;312:156-160.

22. Roseboom TJ, van der Meulen JHP, Osmond C, Barrer DJP, Ravelli ACJ, Bleker OP. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 2000;72:1101-1106.

23. Forsen TJ, Eriksson JG, Osmond C, Barker DJ. The infant growth of boys who later develop coronary heart disease. Ann Med 2004;36:389-392.

24. Secretaría de Salud. Norma Oficial Mexicana NOM–031–SSA2–1999 para la atención a la salud del niño. Diario Oficial 2000 9 de junio: 1-42.

25. WHO. Expert committee on physical status: the use and interpretation of anthropometry: Report of a WHO expert committee. WHO Technical Report Series: 854. Ginebra: WHO, 1995.