Aguado BOM, Milián CD, Cordero EI, Fleite ME

Language: Spanish
References: 7
Page: 17-20
PDF size: 103.63 Kb.

ABSTRACT

Baclground: Anesthesia for correction of spinal deformities is source of concern due to the agression of the patient, specially with respect of blood loss. A pharmacological approach for blood loss prevention has been matter of interest for many authors, using epsilon-aminocaproic acid as antifibrinolytic agent. Goals: To evaluate the effect of this drug as antifibrinolytic agent for surgical correction of scoliosis. Material and methods: Forty four patients were studied, subdivided in two randomized groups. Group I received 5gr of EACA prior skin incision followed by a continous infusion of 1 gr/hour until skin close. Coagulation monitoring was done in three perioperative periods. Intraoperative blodd loss was quantified (ml) using blood collector and weighting of the copresses. In the recovery room blooding was quantified postoperatively 2 and 24 hours later and it was classified as moderate or severe.Results: Blooding was greater in all periods in group II. Coagulation monitoring be haved normally in most of the patients in group I. Hemotocrite values were higher and the amount of blood products used were fever in group I. Conclusion: Blooding was lower in group I; hematocite values were also lower in this group and the number of transfusions was higher in group II. We consider EACA use is an effective blood spore method for patients undergoing this kind of surgery.

REFERENCES

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6. Jordan D, Delphin E, Rose E. Prophylactic epsilon-aminocaproic acid (EACA) administration minimizes blood replacement therapy during cardiac surgery. Anesth Analg 1995; 80 (4): 827-9.

7. Thomas F. Slaughter 1, Charles S. Greenberg: Antifibrinolytic drugs and perioperative hemostasis. Es J HEMATOL 1997; 56:32-36.