1999, Number 3
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Rev Mex Pediatr 1999; 66 (3)
Concentración de electrólitos en el suero de niños intoxicados por picadura de alacrán
Carbajal UJA, Pastrana HE, Chávez RML
Language: Spanish
References: 20
Page: 97-101
PDF size: 122.15 Kb.
ABSTRACT
This study was done in order to determinate the relation between clinical manifestations, serum electrolytes
measurements and electrocardiographic traces of patients bite by scorpions at the moment they went in to the
emergency room.
We evaluated 71 patients who completed the criterions of inclusion the incidence was of 16.74/1000 persons affiliated to our institution and prevalence of 8.73/1,000 cases predominantly during summer with 13.79/1,000 cases. The mean age was of 21.24 ± 12.1 years old, 78.87% of accident’s happen at home. Moderate symptoms were present in 81.69% of patients, severe in 9.85% and low in 8.45%, highest incidence happens in children of 6.26 ± 4 years old (85.71%), there were no deceased.
The average of serum electrolytes titters was of 136.76 ± 8.22 mEq/L Na, 5.03 ± 1.73 mEq/L K and 8.72 ± 1.63 mg/dL Ca. In relation to the symptoms, the severe ones had a hyperkalemia from low to moderate (5.96 ± 2.05 mEq/L). We did not find any difference, between the medias in statistic F of Anova proof.
Alterations of electrocardiographic traces only consisted of arrhythmia (12.82%), segments were, normal (QTc: 0.39 ± 0.04" QRS: 0.06 ± 0.01" and 0.3 ± 0.1 mmv T wave).
Metabolical changes observed didn’t have specific with clinical symptoms and signs. Low to moderate
hyperkalemia and relative hyponatremia without
electrocardiographic signs are present in severe, disease. We recommend to include specific: treatment for correction of this metabolic changes.
REFERENCES
Bases para el tratamiento: En la intoxicación causada por picadura de alacrán y mordedura de serpiente. IMSS, Instituto Bioclon 1996.
Sánchez J. Cien años de la zoología médica. Instituto de seguridad y servicios sociales de los trabajadores del estado. México DF. 1993: 52-79.
Laguna A, Rojas N. Picadura de alacrán, experiencia clínica con 147 niños de Acapulco Guerrero. Rev Med IMSS (Mex) 1983; 21: 270-275.
Martínez AR. Picadura de alacrán en niños: Estudio de 100 casos. Bol Med Hosp Infant Mex 1983; 40: 407-410.
Hernández LA, Ríos OI. Prevalencia de la picadura de alacrán en la Ciudad de Querétaro. Rev Med IMSS (Mex) 1994; 32: 227-231.
Dehesa DM, Possani LD. Scorpionism and a serotherapy in México. Toxicon 1994; 32 (9): 1015-1018.
Noceti F, Ramírez AN, Possani LD, Prestipino G. Characterization of a voltage-dependent potassium channel in squid Shwann cells reconstituted in lipid bilayers. Glia 1995; (1): 33-42.
Cestele S, Sampieri F, Rochat H, Gordon D. Tetrodotoxin reverses brevetoxin allosteric inhibition of scorpion alfa toxina binding on rat sodium channels. J Biol Chen l996; 271 (31): 18329-18332.
Blanc E, Fremont V, Sizun P, Meunier S et al. Solution structure of P01, a natural scorpion peptide structuraly analogous to scorpion toxins specific for apamin-sensitive potassium channel. Proteins 1996; 24 (3): 359-369.
Drira ChS, Ayeb M, Torresani J, Gharbi ChJ. Lipolytic Action of buthus occitanus tunetanus venon: Involvement of the, beta adrenergic pathway. Biochem Biophys Res Common 1996; 4; 226 (1): 280-286.
Gómez LF, Olamendi PT, Zamudio FZ, Possani LD. Two novel toxins from venom of the scorpion Pandinus Imperator show that the N-terminal amino acid sequence is important for their affinites towards shaker B K+ channels. J Membr Biol 1996; 152 (1): 49-56.
Valdivia HH, Martín BM, Ramírez AN, Fletcher PL, Possani LD. Isolation and pharmacological characterization of four novel Na+ channel blocking toxins from the scorpion centruroides. J Biochem Tokyo 1994; 116 (6): 1383-1391.
Dauplais M, Gilquin B, Possani LD, Gurrola-Briones G, Roumestand Ch. Méndez A. Determination of the Three Dimensional Solution Structure of Noxiustoxin: Analysis of Structure Differences with Related Short-Chain Scorpion Toxins. Biochemistry 1995; (34): 16563-16573.
Meki AR, Nassar AY, Rochat HA. Bradykinin potentiating peptide (peptide K12) isloted from the venom of Egyptian scorpion buthus occitanus. Peptides 1995; 16 (8): 1359-1365.
Gómez LF, Olamendi PT, Zamudio FZ, Possani LD. Two novel toxins from the venom of the scorpion pandinus imperator show that: the N-terminal aminoacid sequence is important for their affinities towards shaker B K+ channels. J Membr Biol 1996; 152 (1): 49-56.
American Academy of Pediatrics. Envenomation by the scorpion centruroides exilicauda (C. Sculpturatus): Severe and usual manifestations. Pediatrics 1991; 87 (6): 930-932.
González RS, González HJ y col. Alteraciones electrocardiográficas en sujetos picados por alacrán. Arch Inst Cardiol Mex 1991; 61: 15-20.
Margulis G, Sofer S, Zalstein E, Zucker N, Ilia R, Gueron M. Abnormal coronary perfusion in experimental scorpion envenomation. Toxicon 1994; 32 (12): 1675-1678.
Das S, Nalini P, Ananthakrishnan S, Sethuraman KR, Balachander J, Srinivasan S. Cardiac involvement and scorpion envenomation in children. J Trop Pediatr 1995; 41 (6): 338-340.
Das S, Nalini P, Ananthakrishanan S, Sethuraman KR, Balachander J, Srinvasan S. Scorpion envenomation in children in Southern India. J Trop Med Hyg 1995; 98 (5): 306-308.