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ISSN 0188-2198 (Print)

2008, Number 3

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Rev Mex Cardiol 2008; 19 (3)

Sudden death in hypertrophic cardiomyopathy. Risk stratification

Guzmán-Sánchez CM, González-Pliego JA, Parra-Michel R, Espinosa-Anguiano S, González-López LG

Language: Spanish
References: 41
Page: 126-133
PDF size: 106.54 Kb.


ABSTRACT

Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder caused by mutations in one of at least 12 sarcomeric or nonsarcomeric genes. Is recognized as the most common genetic cardiovascular disease transmitted as an autosomal dominant trait. Epidemiologic studies have shown similar estimates for the prevalence of phenotypically expressed HCM in the adult general population of approximately 0.2% (1:500). Therefore, HCM in fact, is the most common cause of sudden cardiac death (SCD) in the young. Clinical diagnosis of HCM is usually established with echocardiography by demonstrating left ventricular hypertrophy, typically asymmetric in distribution, and associated with a nondilated chamber in the absence of another cardiac or systemic disease capable of producing the magnitude of hypertrophy evident. Recent advances in HCM have promoted new diagnostic and management strategies. Many affected individuals remain asymptomatic throughout life, others develop heart failure symptoms or atrial fibrillation (AF), and some die suddenly. Stratification of sudden death risk is based on the presence of at least 1 of several markers. The implantable cardioverter defibrillator is the most effective treatment for sudden death prevention, and should be considered in patients with either one strong or multiple risk factors.


REFERENCES

  1. Brock RC. Functional obstruction of the left ventricle. Guy’s Hospital Report. 1957; 106: 221-238.

  2. Teare. Asymmetrical hypertrophy of the heart in young adults. Br Heart J 1958; 20: 1-8.

  3. Braunwald E, Lambrew CT, Rockoff SD, Ross JJ, Morrow AG. Idiopathic hypertrophic subaortic stenosis. A description of the disease based upon an analysis of 64 patients. Circulation 1964; 30: 3-119.

  4. Seidman JG, Seidman C. The genetic basis for cardiomyopathy: from mutation identification to mechanistic 0 paradigms. Cell 2001; 104: 55-567.

  5. Maron BJ, McKenna WJ, Danielson GK et al. American College of Cardiology/European Society of Cardiology Clinical Expert Consensus Document on Hypertrophic Cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. J Am Coll Cardiol 2003; 42: 1687-1713.

  6. Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet 2004; 363: 1881-1891.

  7. McKenna WJ, Behr ER. Hipertrophic cardiomyopathy: management, risk stratification and prevention or sudden death. Heart 2002; 87: 169-176.

  8. Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4,111 subjects in the CARDIA study. Circulation 1995; 92: 785-789.

  9. Zou Y, Song L, Wang Z, Ma A, Liu T, Gu H et al. Prevalence of idiopathic hypertrophic cardiomyopathy in China: a population-based echocardiographic analysis of 8,080 adults. Am J Med 2004; 116: 14-18.

  10. McKenna WJ, Deanfield JE. Hypertrophic cardiomyopathy: An important cause of sudden death. Arch Dis Child 1984; 59: 971-975.

  11. Maron BJ, Spirito P. Impact of patient selection biases on the perception of hypertrophic cardiomyopathy and its natural history. Am J Cardiol 1993; 72: 970-972.

  12. Maron BJ, Mathenge R, Casey SA, Poliac LC, Longe TF. Clinical profile of hypertrophic cardiomyopathy identified de novo in rural communities. J Am Coll Cardiol 1999; 33: 1590-1595.

  13. Maron BJ, Spirito P, Roman MJ et al. Evidence that hypertrophic cardiomyopathy is a common genetic cardiovascular disease: prevalence in a community-based population of middle-aged and elderly American Indians (abstract). Circulation 2003; 108: IV-664.

  14. Maron BJ, Shen WK, Link MS et al. Efficacy of implantable cardioverterdefibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy. N Engl J Med 2000; 342: 365-73.

  15. Boriani G, Maron BJ, Win-Kuang S, Spirito P. Prevention of Sudden death in hypertrophic cardiomyopathy but which defibrillator for which patient? Circulation 2004; 110: 438-442.

  16. Maron BJ. Ventricular arrhythmias, Sudden death, and prevention in patients with hypertrophic cardiomyopathy. Current Cardiology Reports 2000; 2: 522-528.

  17. Cecchi F, Maron BJ, Epstein SE. Long-term outcome of patients with hypertrophic cardiomyopathy successfully resuscitated after cardiac arrest. J Am Coll Cardiol 1989; 13: 1283-8.

  18. Kofflard MJ, Ten Cate FJ, van der LC et al. Hypertrophic cardiomyopathy in a large community-based population: clinical outcome and identification of risk factors for sudden cardiac death and clinical deterioration. J Am Coll Cardiol 2003; 41: 987-93.

  19. Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A, NG et al. Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol 2000; 36: 2212-8.

  20. Elliott PM, Blanes JRG, de Mahon NG, Poloniecki JD, McKenna WJ et al. Relation between severity of left ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy. Lancet 2001; 357: 420-4.

  21. Spirito P, Bellone P, Harris KM et al. Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med 2000; 342: 1778-85.

  22. Watkins H, McKenna WJ, Thierfelder L et al. Mutations in alfa-tropomyosin in hypertrophic cardiomyopathy. N Engl J Med 1995; 332: 1058-64.

  23. Sorajja P. Hypertrophic cardiomyopathy: Clinical implications of massive hypertrophy. J Am Soc Echocardiogr 2006; 19: 788-795.

  24. Frenneaux MP. Assessing the risk of sudden cardiac death in a patient whit HCM. Heart 2004; 90: 570-575.

  25. Maron MS, Olivotto I, Betocchi S et al. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003; 348: 295-303.

  26. Frenneaux MP, Counihan PJ, Caforio AL et al. Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy. Circulation 1990; 82: 1995-2002.

  27. Sadoul N, Prasad K, Elliott PM et al. Prospective prognostic assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy. Circulation 1997; 96: 2987-91.

  28. Olivotto I, Maron BJ, Montereggi A et al. Prognostic value of systemic blood pressure response during exercise in a community-based patient population with hypertrophic cardiomyopathy. J Am Coll Cardiol 1999; 33: 2044-51.

  29. Maki S, Ikeda H, Muro A et al. Predictors of sudden cardiac death in hypertrophic cardiomyopathy. Am J Cardiol 1998; 82: 774-8.

  30. Maron BJ, Savage DD, Wolfson JK et al. Prognostic significance of 24 hour ambulatory electrocardiographic monitoring in patients with hypertrophic cardiomyopathy: a prospective study. Am J Cardiol 1981; 48: 252-7.

  31. McKenna WJ, England D, Doi YL et al. Arrhythmia in hypertrophic cardiomyopathy. I: Influence on prognosis. Br Heart J 1981; 46: 168-72.

  32. Cecchi F, Olivotto I, Montereggi A et al. Prognostic value of non-sustained ventricular tachycardia and the potential role of amiodarone treatment in hypertrophic cardiomyopathy: assessment in an unselected non-referral based patient population. Heart 1998; 79: 331-6.

  33. McKenna WJ, Franklin RC, Nihoyannopoulos P et al. Arrhythmia and prognosis in infants, children and adolescents with hypertrophic cardiomyopathy. J Am Coll Cardiol 1988; 11: 147-153.

  34. Fananapazir L, Chang AC, Epstein SE et al. Prognostic determinants in hypertrophic cardiomyopathy. Prospective evaluation of a therapeutic strategy based on clinical, Holter, hemodynamic, and electrophysiological findings. Circulation 1992; 86: 730-740.

  35. Saumarez RC, Chojnowska L, Derksen R et al. Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation. Circulation 2003; 107: 2595-2600.

  36. Yetman AT, McCrindle BW, MacDonald C et al. Myocardial bridging in children with hypertrophic cardiomyopathy -a risk factor for Sudden death. N Engl J Med 1998; 339: 1201-1209.

  37. Dilsizian V, Bonow RO, Epstein SE et al. Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 1993; 22: 796-804.

  38. Yamada M, Elliott PM, Kaski JC et al. Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy. Relationship to clinical presentation and outcome. Eur Heart J 1998; 19: 500-7.

  39. Moon JC, McKenna WJ, McCrohon JA et al. Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol 2003; 41: 1561-7.

  40. Ackerman MJ, VanDriest SL, de Ommen SR et al. Mutations in hipertrophic cardiomyopathy. J Coll Cardiol 2002; 39: 2042-2048.

  41. Nishimura RA, Holmes Jr DR. Hypertrophic obstructive cardiomyopathy. N Engl M Med 2004; 350: 1320-1327.




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