Ustáriz-González O, Furno-Sola F, Quiroz-Mercado H

Language: Spanish
References: 0
Page: 268-271
PDF size: 498.73 Kb.

ABSTRACT

The leading causes of blindness are retinal and choroidal diseases manifesting abnormal vessels permeability and growth. Angiogenesis has a causal role in many diseases, including neovascular age-related macular degeneration (AMD), proliferative diabetic retinopathy (PDR), and retinopathy of prematurity (ROP). Angiogenesis is a highly complex, dynamic process regulated by a number of pro and antiangiogenic molecules. The vascular endothelial growth factor (VEGF) and its receptors play a vital role in normal and pathologic angiogenesis. Therapeutic antagonism of VEGF for treating retinal neovascularization, choroidal neovascularization (CNV), and macular edema is to inhibit VEGF activity by competitively binding VEGF with a specific neutralizing anti-VEGF antibody.