medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2007, Number 5

<< Back Next >>

Rev Mex Oftalmol 2007; 81 (5)

Características clínicas y epidemiológicas del retinoblastoma en Guatemala

Zimmermann-Paiz MA

Language: Spanish
References: 20
Page: 267-271
PDF size: 92.43 Kb.


ABSTRACT

Introduction: Retinoblastoma is the most common malignant ocular tumor in childhood. In Guatemala the real frequency and the presentation characteristics are ignored.
Material and methods: A retrospective and descriptive study was carried out. From 1996 to 2006 a total of 113 patients with retinoblastoma diagnosis were studied at the Hospital de Ojos y Oídos Dr. Rodolfo Robles V., located in the capital of Guatemala.
Results: 60 cases were male and 53 female (M:F ratio1.13:1). The age range at diagnosis was 1-96 months ( Median 29.31). Unilateral presentation in 68.1% and bilateral in 31.9% cases. Median age at diagnose in unilateral cases 34.1 months and in bilateral cases 19.25 months. 93.8% of cases without family history of retinoblastoma. 100% of cases with affection in both eyes had family history. The main presentation form was leucocoria in 59.3%.
Conclusion: The characteristics of retinoblastoma in Guatemala are similar to those observed in other developing countries. The necessity to create a national system for early retinoblastoma detection exists. This would support an early, standardized and multidisciplinary treatment for this patients.


REFERENCES

  1. Grabowski EF, Abramson DH. Intraocular and extraocular retinoblastoma. Hematol Oncol Clin North Am 1987; 1:721-35.

  2. Mejía Arangure JM, Flores Aguilar H, Juárez Muñoz I y cols. Age of onset of different malignat tumors in childhood. Rev Med Inst Mex Seguro Soc 2005; 43(1):25-37.

  3. Abramson DH, Schefler AC. Update on retinoblastoma. Retina 2004; 24:828-848.

  4. Cerecedo Díaz F, López Aguilar E, Rivera Márquez H y cols. Survival and clinical features of retinoblastoma. An Pediatr (Barc) 2003; 58(1):3-9.

  5. Amozorrutia-Alegría V, Bravo-Ortiz JC, Vásquez-Vivieros J y cols. Epidemiological characteristics of retinoblastoma in children attending the Mexican Social Security Institute in Mexico City, 1990-94. Pediatr Perinat Epidemiol 2002;16(4):370-4.

  6. Devesa S. The incidence of Retinoblastoma. Am J Ophthalmol 1975; 80:263-5.

  7. Fajardo-Gutierrez A, Sandoval-Mex AM, Mejía-Arangue JM y cols. Clinical and social factors that affect the time to diagnosis of Mexican children with cancer. Med Pediatr Oncol 2002; 39(1):25-31.

  8. Pratt CB. Management of malignant solid tumors in children. Pediatr Clin North Am 1972; 19:1141-55.

  9. Luna-Fineman S, Slowing K, Valverde P y cols. Pediatric Cancer in Guatemala: a retrospective study. Med Pediat Oncol 1997; 29:353.

  10. Chantada G, Fandiño A, Manzitti J, Urrutia L, Schvartzman E. Late diagnosis of retinoblastoma in a developing country. Arch Dis Child 1999; 80:171-174.

  11. Guerra Marín B, Salazar León J, Ordaz Favila JC. Retinoblastoma: Presentación de 405 casos y revisión de la literatura. Parte I: Genética. Rev Mex Oftalmol 2001; 75(2):46-56.

  12. Leal Leal C, Flores Rojo M, Medina Sansón A, Cerecedo Díaz F y cols. A multicenter report from the Mexican Retinoblastoma Group. Br J Ophthalmol 2004; 88:1074-1077.

  13. Gunalp I, Gunduz K, Arslan Y. Retinoblastoma in Turkey: diagnosis and clinical characteristics. Ophthalmic Genet 1996; 17:21-7.

  14. Bhugri Y, Muzaffar S, Ahmed R, Ahmed N, Bhurgri H y cols. Retinoblastoma in Karachi, Pakistan. Asian Pac J Cancer Prev 2004; 5(2):159-163.

  15. Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz Francois, Desjardins L. Retinoblastoma. Orphanet J Rare Diseases 2006, 1:31.

  16. Gomez Martinez R, Leal CA, Rivera Luna R, Cárdenas RS, Martínez AB, Medina A. Epidemiological aspects of bilateral retinoblastoma. Gac Med Mex 1995; 131(5-6):527-31.

  17. Schultz K, Ranales S, Neglia J y cols. Increased relative frecuency of retinoblastoma at a rural regional referal hospital in Miraj Maharashtra India. Cancer 1993; 72:282-286.

  18. Stiller C, Parkin D. Geographic and ethnic variations in the incidence of childhood cancer. Brit Med Bull 1996; 52:682-703.

  19. Wilson MW, Haik BG, Rodriguez Galindo C. Socioeconomic impact of multidisciplinary management of retinoblastoma. Pediatrics 2006; 118(2):331-6.

  20. Ramírez Ortiz MA, Ruiz Freyre G, Rodríguez Almaraz M. Costo del tratamiento del retinoblastoma en México. Rev Mex Oftalmol 2005; 79(4):206-210.




2020     |     www.medigraphic.com