Hernández DMSE, Cárdenas ARR

Language: Spanish
References: 7
Page: 192-195
PDF size: 122.89 Kb.

ABSTRACT

Objective: To describe the combination of photodynamic therapy and bevacizumab (Avastin) intravitreal injection in the treatment of an adult Coats’ disease case with macular involvement.
Results: After 1 year post-treatment follow-up, a complete remission of retinal exudative and hemorrhagic lesions was observed with ablation of telangiectasias. The final best corrected visual acuity was 20/20.
Discussion: Although argon laser remains as the mainstay of therapy for Coats’ disease, cases in which macular area is threatened or involved, combined photodynamic therapy with bevacizumab may be an alternative, more promising choice for these patients, without the sequelae produced by the thermic effect of laser energy.

REFERENCES

1. Coats G. Forms of retinal dysplasia with massive exudation. R Lond Ophthalmol Hosp Rep 1908; 17:440.

2. Haller J. Coats Disease. En: Ryan’s Retina. Tercera edición. St. Louis, Mosby; 2005. P 1441-1448.

3. Morales AG: Coats Disease: Natural history and results of treatment. Am J Ophthalmol 1965; 60:855.

4. Schmidt-Erfurth UM, Kusserow C, Barbazatto IA, Laqua H. Benefits and complications of photodynamic therapy of papillary capillary hemangiomas. Ophthalmology 2002; 109(7):1256-66.

5. Ahmadieh H, Taei R, Soheilian M, Riazi-Esfahani M, Karkhane R y cols. Single session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone for neovascular age-related macular degeneration. BMC Ophthalmol 2007; 7(7):10.

6. Costa RA, Jorge R, Calucci D, Melo LA Jr, Cardillo JA y cols. Intravitreal bevacizumab (Avastin) in combination with verteporfin photodynamic therapy for choroidal neovascularization associated with age-related macular degeneration (IBeVe Study). Graefes Arch Clin Exp Ophthalmol 2007; 245(9): 1273-80.

7. Lazic R, Gabric N. Verteporfin therapy and intravitreal bevacizumab combined and alone in choroidal neovascularization due to age-related macular degeneration. Ophthalmology 2007; 114(6):1179-85.