medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2003, Number 3

Next >>

Rev Mex Oftalmol 2003; 77 (3)

Efecto de la aplicación tópica de 5-fluorouracilo en la prevención de la cicatrización exagerada en cirugía de estrabismo en conejos

Flores-Gutiérrez OM, Pérez–Pérez JF, Arroyo–Yllanes ME, Rodríguez–Reyes AA, Campos García-Rojas C

Language: Spanish
References: 12
Page: 89-93
PDF size: 503.90 Kb.


ABSTRACT

Objective: 5-Fluoracile efficacy and the over-healing process in the adhesion syndrome posterior to strabismus surgery in rabbits were evaluated.
Material and methods: Inferior rectus and oblique muscles had surgery in 16 eyes of 8 rabbits. By randomised distribution 5-Fluoracile was administered in one eye and saline solution in the fellow one. The healing process and clinical fibrosis were examined by histopathological techniques.
Results: Vascularization, movement limitation and fibrosis did not show significant differences but healing and fibrosis showed significant differences by histopathology.
Conclusions: 5-Fuoracil may be useful in subjects with previous surgeries. It decreases healing and fibrosis without complications.


REFERENCES

  1. Mora, J.S.; Sprunger, D.T.: Intraoperative Sponge 5–Fluorouracil to Reduce Posoperative Scarring in Strabismus Surgery. J AAPOS, 1997; 1(92):97.

  2. Dunlap, E. A.: Surgery of Muscle Adhesions and Effects of Multiple O. Brit J Ophthalmol, 1974; 58:307-312.

  3. Quintana–Pali, L.: Iconografía estrabológica: Síndrome de adhesión. Rev Mex Oftalmol, 1990; 64 (5):187–188.

  4. Elsas, F .J.; Gowda, C.: Synthetic Polypeptide Sleeve for Strabismus Surgery. J Pediatr Ophthalmol Strabismus, 1992; 29:284–286.

  5. Searl, S. S.; Metz, H. S:. The Use of Sodium Hyaluronate as a Biologic Sleeve in Strabismus Surgery. Ann Ophthalmol, 1987;. 19:259–268.

  6. Yaacobi, J.; Hamed, M.: Reduction of Postoperative Adhesions Secondary to Strabismus Surgery in Rabbits. Ophthalmic Surg, 1995; 26:237–240.

  7. Cruz, A. O.; Matkoyich, L.: Effects of Intraoperative Topical Mitomycin C on Strabismus Surgery in the Rabbit: A Preliminary Study. Ophthalmic Surg, 1995; 26:237–240.

  8. Urban, R. C.; Kaufman, L. M.: Mitomycin in the Treatment of Hypertrophic Conjunctival Scars After Strabismus Surgery. J Pediatr Ophthalmol Strabismus, 1994; 31: 96–98.

  9. Brooks, S. E.; Ribeiro, G.: Fat Adherence Syndrome Treated With Intraoperative Mitomycin – C: A Rabbit Model. J Pediatr Ophthalmol Strabismus, 1996; 33:21–27.

  10. Smith, S.; D’Amore, P. A.: Comparative Toxicity of Mitomicin C and 5–Fluorouracil in Vitro. Am J Ophthalmol, 1994; 118:332–337.

  11. Khaw, P .T.; Doyle, J. W.: Prolonged localized Tissue effects from 5–Minute Exposures to Fluorouracil and Mitomicin – C. Arch Ophthalmol, 11:263–267.

  12. Mora, J. S.; Nguyen, N.: Trabeculectomy with Intraoperative Sponge 5–Fluorouracil. Ophthalmology, 1996; 103:963–970.




2020     |     www.medigraphic.com