2003, Number 3
Rev Mex Oftalmol 2003; 77 (3)
Efecto de la aplicación tópica de 5-fluorouracilo en la prevención de la cicatrización exagerada en cirugía de estrabismo en conejos
Flores-Gutiérrez OM, Pérez–Pérez JF, Arroyo–Yllanes ME, Rodríguez–Reyes AA, Campos García-Rojas C
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ABSTRACTObjective: 5-Fluoracile efficacy and the over-healing process in the adhesion syndrome posterior to strabismus surgery in rabbits were evaluated.
Material and methods: Inferior rectus and oblique muscles had surgery in 16 eyes of 8 rabbits. By randomised distribution 5-Fluoracile was administered in one eye and saline solution in the fellow one. The healing process and clinical fibrosis were examined by histopathological techniques.
Results: Vascularization, movement limitation and fibrosis did not show significant differences but healing and fibrosis showed significant differences by histopathology.
Conclusions: 5-Fuoracil may be useful in subjects with previous surgeries. It decreases healing and fibrosis without complications.