Aguirre HR, Medina CL, Montoya FH, Sandoval LJG, Padilla RM, García SV, Jáuregui MA

Language: Spanish
References: 10
Page: 311-316
PDF size: 174.53 Kb.

ABSTRACT

Objective: To establish the association between high-grade intraepithelial lesions and cervical-uterine-cancer, and the infection by human papillomavirus, genetic antecedents, socioeconomics, sexual behavior and gynecology and obstetrics factors in women of the State of Nayarit, Mexico.
Materials and methods: With a case-control design were studied 66 cases of high-grade intraepithelial lesions and cervical-uterine-cancer, and 132 controls. The information upon the risk factors was obtained by the application of a structured questionnaire. Polymerase Chain Reaction executed the virus identification. In the statistical analysis the association was obtained by odds ratio. The statistical significance was evaluated by the chi-square-Fisher and Student t tests, and multivariate logistic regression was used to explain the factors’ influence.
Results: In women with high-risk squamous intraepithelial lesions and cervical-uterine-cancer, the most frequently high-risk human papillomavirus found were: 18, 35, 58, 16, 31, 33 and 51.
Conclusions: Familial data of cervical-uterine cancer, socioeconomic level, number of sexual partners, data of sexual transmitted diseases, and infection due to human papillomavirus 18 and 35 are the factors related to high-risk squamous intraepithelial lesions and cervical-uterine-cancer.

REFERENCES

1. Boyle P. Global burden of cancer. Lancet 1997;349(Suppl 2): SII23-26.

2. Norma Oficial Mexicana NOM-014-SSA2-1994, para la prevención, detección, diagnóstico, tratamiento, control y vigilancia epidemiológica del cáncer cervicouterino. Diario Oficial de la Federación, México, 6 de marzo de 1998. (Disponible en línea en: http://www.salud.gob.mx/unidades/cdi/nom/014ssa24.html).

3. González SJL, Chávez BJ, Hernández HDM, Martínez SS, et al. Infección por virus del papiloma humano de alto y bajo riesgo en mujeres con NIC. Características diferenciales. Ginecol Obstet Mex 2002;70:11-16.

4. Torres LA, Rojo HG, Torres RA, Hurtado EG, et al. Cáncer del cuello uterino. Panorama actual de su epidemiología y de sus factores de riesgo. Ginecol Obstet Mex 2004;72:466-74.

5. Munoz N, Bosch FX, Sanjose S, Herrero R, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348(6):518-27.

6. Montoya FH, Suárez RAE, Ramírez MMP, Arévalo LI, et al. Detección de papilomavirus humano tipos 16, 18, 35 y 58 en cáncer cervicouterino y lesiones escamosas intraepiteliales de alto grado en el occidente de México: correlación clínicomolecular. Ginecol Obstet Mex 2001;69:137.

7. Bosch FX, Manos MM, Munoz N, Sherman M, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group. J Natl Can Inst 1995;87(11):796-802.

8. Tamayo ALS. Asociación y predicción del riesgo de lesión intraepitelial escamosa y cáncer cervicouterino en función de los factores: infección por el virus del papiloma humano, ginecoobstétricos, comportamiento sexual, sociodemográficos y antecedentes genéticos en mujeres mayores de 15 años. Estado de Colima, México, 2002. Tesis doctoral. Universidad de Colima, 2002.

9. Hernández HDM, Hernández AFR, Ornelas BLA, González LG, et al. Cáncer del cuello uterino. Factores sociales, clínicos y reproductivos asociados con lesiones precursoras. Rev Med IMSS 2001;39(4):325-33.

10. Servicios de Salud de Nayarit. Atlas epidemiológico de la mortalidad en Nayarit, 2004. Tepic SSN, 2005.