Jiménez VH, Domínguez V, López KX

Language: Spanish
References: 0
Page: 66-77
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ABSTRACT

Primary central nervous system lymphoma (PCNSL) was initially described as perivascular sarcoma. PCNSL is and aggressive non-Hodgkin’s lymphoma that arise in brain, leptomenianges, eyes, or spinal cord. The large majority are B cells lymphomas. The incidence is 0.43:100,000 per year but seems to be increasing. PCNSL constitutes between 1% and 6% of malignant tumors of the central nervous system. The use of chemotherapy has significantly increased survival of patients as compared with radiotherapy alone. Methotrexate (MTX)- based chemotherapy yields favorable results and is associated with significantly lower therapy-related toxic effects. Leptomeningeal lymphoma and intraocular lymphoma are topics of particular relevance in PCNSL. HIV-related PCNSL prognosis has improved as result of the use of high active antiretroviral therapy and MTX- based chemotherapy.