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2007, Number 6

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Med Int Mex 2007; 23 (6)

Incidence and prognosis of invasive candidiasis in non-neutropenic patients in intensive therapy

Chávez GA, Cabrera RA, Marín RMC, Villagómez OA, Méndez RR, Guzmán GR
Full text How to cite this article

Language: Spanish
References: 9
Page: 481-485
PDF size: 123.02 Kb.


Key words:

Invasive candidiasis.

ABSTRACT

Background: The nosocomial infections due to fungus have been increased in the last two decades and the intensive care units (ICU) are the major incidence sites inside the hospitals.
Objective: To determine the incidence and the prognosis of patients with Candida infections admitted in ICU.
Design: Prospective study done in an Intensive Care Unit during the period of January 1st 2004 to December 31th 2005.
Patients and methods: Were included to the study all the patients booked in ICU with development of Candida during their stay. We considered that the patients developed colonization or Candida infection in any site if fulfilled the criteria indicated by the International Sepsis Forum Consensus Conference
Results: During the period 2004-2005, were admitted in ICU 567 patients. In 148 patients the sepsis diagnoses were considered and 24 of them (16.2%) were reported development some specie of Candida. A 66% of the patients were male and 44% female with average age of 60 years old . The main diagnoses were: abdominal sepsis, severe pneumonia and neuroinfection post-craneal trauma. 37.5% of these patients died by sepsis related to Candida.
Conclusion: The incidence of invasive Candida in this intensive care is 4.2% and the mortality of 37.5%. Is important to know the local epidemiology related to the incidence, risk factors, treatment answers and forecasting, with the intention to decrease the morbility and mortality associated to this infection.


REFERENCES

  1. Vincent JL. Epidemiology, diagnosis and treatment of systemic Candida infection in surgery patients under intensive care. Intensive Care Med 1998;24:206-16.

  2. Petri MG. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients. Intensive Care Med 1996;28:317-25.

  3. Marchetti O, Bille J, fluckiger U. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. Clin Infect Dis 2004;38:311-20.

  4. Hajjeh RA, Sofair AN, Harrison LH, Lyon GM, et al. Incident of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J Clin Microbiol 2004;42:1519-27.

  5. Jorge G. Prevention of severe Candida Infections in non-neutropenic, high-risk, critically ill patients. Intensive Care Med 2002;28:1708-17.

  6. Calandra T. Cohen J. The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit. Crit Care Med 2005;33:1538-48.

  7. Álvarez-Lerma F. Epidemiología de la infección en el paciente crítico. En: Álvarez-Lerma F (editor). Infecciones fúngicas en pacientes críticos. Madrid: Ergon, 2002;pp:7-22.

  8. Petri MG, Köning J, Moecke HP, Gramm HJ, et al. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients. Intensive Care Med 1997;23:317-25.

  9. Marchetti O, Bille J, Fluckiger U. Epidemiology of candidemia in Swiss terciary care hospitals: secular trends, 1991-2000. Clin Infect Dis 2004;38:311-20.




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Med Int Mex. 2007;23