Language: English
References: 4
Page: 170-171
PDF size: 254.10 Kb.

Text Extraction

Trichophyton rubrum is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
They recognize antigens through Toll like receptors (TLR) (3). The activation of this TLR, present on the surface of the keratinocytes, induce the expression of different pro-inflammatory cytokines, costimulatory molecules and antimicrobial peptides such as beta ®-defensins (4).

REFERENCES

1. Arenas R., Dermatofitosis en México. Rev Iberoam Micol 2002; 19: 63-67.

2. Kupper T. and Fuhlbrigge R. Immune surveillance in the skin: mechanims and clinical consecuences. Nat Rev Immunol 2004; 4: 211-222

3. Kôllish G., Naderi B., Voelcker V., Wallich R., Behrendt H., Ring J., Bauer S., Jacob T., Mempel M. and Olelrt M. Various members of the Toll-Like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology 2005; 114: 531-541.

4. Akira, S. and Takeda K. 2004. Toll-like Receptor Signalling. Nature Reviews Immunology 4:499-511.