2008, Number 5
salud publica mex 2008; 50 (5)
Infección por Virus de Papiloma Humano en hombres de Brasil, México y EUA.
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To assess Human Papillomavirus (HPV) type
distribution among men ages 18 years and older recruited
from three different countries utilizing a common protocol
for sampling HPV detection, and to evaluate whether HPV
detection differs by age and country. Material and Methods.
The study protocol includes a pre-enrollment run-in visit, a
baseline (enrollment) visit, and nine additional visits after
enrollment scheduled six months apart. For this analysis, the
ﬁrst 1 160 men who completed both the run-in and baseline
visit were included. To maximize sampling and prevent fraying
of applicators, three different applicators were utilized to
sample the external genitalia of participants among different
anatomic sites. These samples were later combined to form a
single sample for the detection of HPV using polymerase chain
reaction (PCR) for ampliﬁcation of a fragment of the HPV L1
Among 1 160 men from Brazil, Mexico, and with 12.0% oncogenic types only, 20.7% non-oncogenic types
only, 17.8% both oncogenic and non-oncogenic, and 14.7%
unclassiﬁed infections. Multiple HPV types were detected in
25.7% of study participants. HPV prevalence was higher in
Brazil (72.3%) than in the U.S. (61.3%) and Mexico (61.9%).
HPV 16 (6.5%), 51 (6.5%), and 59 (5.3%) were the most commonly
detected oncogenic infections, and HPV 84 (7.7%),
62 (7.3%), and 6 (6.6%) were the most commonly detected
non-oncogenic infections. Overall HPV prevalence was not
associated with age. However, signiﬁcant associations with
age were observed when speciﬁc categories of oncogenic,
non-oncogenic, and unclassiﬁed HPV infections were considered.
Studies of HPV type distribution among
a broad age range of men from multiple countries is needed
to ﬁll the information gap internationally with respect to our
knowledge of HPV infection in men.
the United States (U.S.), overall HPV prevalence was 65.2%;
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