2008, Number 6
Acta Ortop Mex 2008; 22 (6)
García-Reyna JC, Rico MG, Vega GIF, Linares LM, Delgado CEA, Romero RR
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ABSTRACTIntroduction: (99m)Tc-tetrofosmin is an efficient agent as a tumor marker. Several studies have proven its efficiency in detection and localization of tumors of the breast, larynx, thyroid, parathyroid glands, lung, brain, skin, lymphatic and musculoskeletal tissues with a sensitivity and specificity of 95% to 100%. It is used as a predictor of therapy efficacy and to localize remaining and recurrent tissue as well as local and distant extension. Objective: To determine the sensitivity, specificity and predictive values of the three-phase 99mTc-Tetrofosmin scan in detection of malignant lesions of the musculoskeletal tissue. Methods: Seventy-three patients of both genders with suspected malignant musculoskeletal lesions were studied by three-phase (vascular, tissue and delayed images) 99mTc-tectrofosmin scans. Results: One-hundred-percent sensitivity, 67.3% specificity, 55% positive predictive value, and 100% negative predictive value. Conclusion: Three-phase 99mTc-tectrofosmin scan is useful in detection of malignant lesions of the musculoskeletal system due to its high sensitivity and positive predictive value. Nevertheless, benign pathology such as active inflammation is a source of false positives and the attending physician must consider the aid of complementary studies such as histopathology.