2008, Number 39
Combined COPP/EBV treatment followed by low dose radiotherapy in 100 children with Hodgkin’s lymphoma
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ABSTRACTObjective: To evaluate the results of the efficacy and feasibility of the COPP/EBV protocol with low dose Rt in children with Hodgkin’s lymphoma treated in 13 health cooperative group centers in Venezuela.
Patients and Methods: From January 2000 to January 2006 the Pediatric Multidisciplinary Hemato-Oncological Cooperative Group in Venezuela treated 100 children who suffered from Hodgkin’s lymphoma. Their mean age was 11.5 years, with a male-female relation of 1.9:1. The prognostic factors were: male gender 66%; clinical stages IIB, IIIB, IVA or B 56%; mediastinal mass ‹ 30% (MMV) 17%; GB›13.5 x 109/L 8%; Hb ‹11 g/dl. Favorable group (FG): ‹ 3 prognostic factors, 42%; unfavorable group (UG): › 3 prognostic factors or clinical stage IV or MMV, 58% According to the clinical stage and the prognostic factors, three groups were classified.
Results: Total group: complete remission 88%, progression 7%, relapse 5%, mortality 10%. Group 1: free of events survival 80%, total survival 86%. Group 2: free of events survival 68%, total survival 85%. Group 3: free of events survival 70%, total survival 85%.
Conclusions: The COPP/EBV treatment plan associated to low doses of Rt in favorable cases produce results comparable to those reported in the literature, which is not the case in the unfavorable group. In these cases the combinations of chemotherapies has a higher effectiveness.
Landman Parker J, Pacquement H, Leblanc T, Habrand JL, et al. Localized childhood Hodgkin’s disease: response-adapted chemotherapy with etoposide, bleomycin, vinblastine and prednisone before low dose radiation therapy. Results of the French Society of Pediatric Oncology Study MDH90. J Clin Oncol 2000;18:1500-7.