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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2008, Number 05

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Ginecol Obstet Mex 2008; 76 (05)

Comparative analysis of pregnancy rate/captured oocytes in an in vitro fertilization program

Kably AA, Estévez GS, Carballo ME, Durán ML
Full text How to cite this article

Language: Spanish
References: 9
Page: 256-260
PDF size: 224.91 Kb.


Key words:

in vitro fertilization, oocytes, embryo.

ABSTRACT

Background: Since in vitro fertilization/embryo transfer is used as a common assisted reproductive technique there have been attempts to increase its success rate. One way is to obtain more good quality mature ovules to fertilize them, and two to three good quality embryos to transfer.
Objective: To determine if the number of retrieved oocytes is related with the pregnancy rate in IVF-ET.
Patients and methods: Reproductive and descriptive study; 172 patients in the IVF program were included. Whole patients had ovary stimulation with FSHr and antagonist multidose protocol. Five study groups were considered depending on the oocyte number retrieved. Data were analized and correlated with fertilization and pregnancy rate.
Results: There were no statistical differences among age, body mass index, percentage of mature oocyte, fertilization rate, embryo cell stage or basal levels of LH and Estradiol. Group three showed the highest pregnancy rate (64.29%) nevertheless group five had major number of embryo transferred (2.97 ± 0.54 vs 3.17 ± 0.45, p = 0.21). According to FSH doses given, group one had statistical difference related to group three, with higher dose (54.1 vs 62.1). According to previous studies, related to the number of oocyte retrieved, the possibility of pregnancy is higher with more than 13 oocytes retrieved (OR: 0.9 IC 95%: 0.4 -1.7).
Conclusions: Pregnancy rate is higher when ten to fifteen oocytes were retrieved.


REFERENCES

  1. Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine. ASRM/SART registry 1999 results. Fertil Steril 2002;78:918-31.

  2. Gurgan T, Urman B, Yarali H Duran HE. Follicle-estimulating hormone levels on cycle day 3 to predict ovarian response in women undergoing controlled ovarian hyperstimulation for in vitro fertilization using a flare-up protocol. Fertil Steril 1994;61:880-5.

  3. Ruiz AJ, Carballo ME, Durán ML, Kably AA. Variables determinantes del éxito en la reproducción asistida. Ginecol Obstet Mex 2006;73:137-44.

  4. Kably AA, Ruiz AJ, Carballo ME, Durán ML. Valor de las características morfológicas del cuerpo polar como factor de predicción del desarrollo embrionario. Ginecol Obstet Mex 2004;72:637-44.

  5. Van der Gast MH, Eijkemans MJC, Van der Net J, Boer EJ, et al. Optimum number of oocytes for a succesful first IVF treatment cycle. Reproductive Bio Medicine Online 2006;13:476-80.

  6. Weissman A, Ravhon A, Biran G, Levin D, et al. Follicular growth and development under continous gonadotropin-releasing hormone antagonist administration. Fertil Steril 2007, article in press.

  7. Schoolcraft W, Surrey E, Minjarez D, Stevens J, et al. Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozoleprotocol? Fertil Steril 2007, article in press.

  8. Kolibianakis E, Albano C, Kahn J, Camus M, et al. Exposure to high levels hormone and estradiol in the early follicular phase of gonadotropin releasing hormone antagonist cycles is associated with a reduced chance of pregnancy. Fertil Steril 2003;79:873-80.

  9. Peña J, Chang P, Chan L, Zeitoun K, et al. Supraphysiogical estradiol levels do not affect oocyte and embryo quality in oocyte donation cycles. Hum Reprod 2002;17:83-87.




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Ginecol Obstet Mex. 2008;76