medigraphic.com
Anales de Otorrinolaringología Mexicana

2008, Number 3

<< Back Next >>

Otorrinolaringología 2008; 53 (3)

Sildenafil effects on diabetic rats’ skin flans

Navarro MMC, Glicerio GJ, González GJA, Woge JC, Contreras GFJ

Language: Spanish
References: 6
Page: 103-107
PDF size: 305.17 Kb.


ABSTRACT

Background
Patients with diabetes are usually submitted to reconstructive procedures across skin flaps, due to ablation tumors of head and neck or craniofacial trauma.
Objective
To evaluate the effect of sildenafil in the diabetic rats skin flap viability.
Material and methods
We used 20 Egyptian rats that were divided in four groups: healthy rats with and without sildenafil and diabetic rats with or without sildenafil. A McFarlane procedure skin flap (3x10 cm) was made and it was placed at its original position by suture. Immediately post surgery, every 24 hours until seven day, sildenafil citrate was administrated to the respective groups. The rats were photographed at days 1, 3, 5. The skin flap was removed and it was photographed at 7 day. The degree of necrosis was analyzed with Image J. software. (National Institute of Health).
Results
The digital analysis showed a minor degree of necrosis in the healthy and diabetic group of rats who received sildenafil citrate.
Conclusions
Sildenafil is an effective drug that improves the skin flap viability, thus we consider it useful for patients that undergo reconstructive surgery.


REFERENCES

  1. Yang D, Morris S. Comparison of two different delay procedures in a rat skin flap model. Plast Reconstr Surg 1998;102(5):1591-7.

  2. Vural E, Key M. Complications, salvage and enhancement of local flaps in facial reconstruction. Otolaryngol Clin North Am 2001;34:739-51.

  3. Um SC, Suzuki S, Toyokuni S, Kim BM, et al. Involvement of nitric oxide in survival of random pattern skin flap. Plast Reconstr Surg 1998;101:785-92.

  4. Sarifakioglu N, Gokrem S, Ates L, Akbuga UB, Aslan G. The influence of sildenafil on random skin flap survival in rats: an experimental study. Br J Plast Surg 2004;57:769-72.

  5. Pang CY, Forrest CR, Morris SF. Pharmacological augmentation of skin flap viability: a hypothesis to mimic the surgical delay phenomenon or a wishful thought. Ann Plast Surg 1989;22:293-306.

  6. McFarlane RM. The design of the pedicle flap in the rat to study necrosis and its prevention. Plast Reconstr Surg 1965;35:177-82.




2020     |     www.medigraphic.com