Nicolae C onstantine Paulescu, insulin discovery and the 1923 Nobel Prize

Arturo Olvera Acevedo; Mayra Pérez Pérez; María del Pilar Cruz Domínguez; Olga Lidia Vera Lastra

2008, Number 2

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Med Int Mex 2008; 24 (2)

Nicolae C onstantine Paulescu, insulin discovery and the 1923 Nobel Prize

Olvera AA, Pérez PM, Cruz DMP, Vera LOL

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Language: Spanish
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Page: 165-171
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ABSTRACT

Relapsing polychondritis is a chronic and progressive autoimmune disease characterized by recurrent inflammatory attacks and destruction of cartilaginous structures and connective tissue, produced by circulating complexes, antibodies against type II, IX, XI collagen in association with HLA DR4. RP is considered a rare disease with only 600 cases reported in the world literature. In Mexico 18 cases have been reported. The cause is unknown, although an autoimmune mechanism has been proposed.