medigraphic.com
Colegio de Medicina Interna de México.

2008, Number 3

<< Back Next >>

Med Int Mex 2008; 24 (3)

holesterol serum levels and suicidal attempt

Ramírez CS, Jiménez SN, Lozano NJJ, Rubio GAF

Language: Spanish
References: 12
Page: 181-185
PDF size: 181.47 Kb.


ABSTRACT

Background: Suicide among young mexican population represents the 4th cause of death, and it has increased up to 200% in the last 30 years. Principal factors responsible for higher incidence of suicide are: break up of family ties, systemic-psychiatric diseases, and genetic and biochemical factors (hypocholesterolemia). Plasma cholesterol is a broad available test in Mexico, which may be potential early marker for suicide risk.
Objective: To establish the relation between serum concentration of cholesterol and suicide attempt.
Patients and methods: Cases and controls design. We collect data of 63 patients with suicide attempt admitted at hospitals of Xoco, Ticoman and Balbuena, from March 2004 to March 2007, to measure lipids, and were compared with 63 controls with same age and sex.
Results: Odds ratio for cholesterol lower than 200 mg/dL was 10. Difference proportion between cholesterol lower than 200 mg/dL and suicide was 10, IC 95% 8.76 to 11.24, whit χ2 = 16.77 for one degree of freedome and a of 0.05 there was critical value 3.84, with IC 95% 13.07 to 16.99. With Student t for total cholesterol with a value of 3.45, p de 0.005, IC 95% 2.94 to 3.95.
Conclusion: Cholesterol lower than 200 mg/dL is an independent risk factor for suicide attempt.


REFERENCES

  1. Gunnell D, Frankel S. Prevention of suicide: aspirations and evidence. BMJ 1999;308:1227-33.

  2. INEGI 1997. Tablas de morbilidad y mortalidad según sus causas en México.

  3. Pirkola S, Itsometsa E, Henriksson M, Marttunen M, et al. The treatment received by substance-dependent male and female suicide victims. Scandinavic Psychiatry Act 1999;(3):207-13.

  4. Steegmans PH, Hes AW, Bac AA, van der Does E, Grobbee DE. Higher prevalence of depresive symptoms in middleaged men with low serum cholesterol levels. Psychosom Med 2000;62(2):205-11.

  5. Mejía J, Fajardo A, Gómez A, Cuevas M, et al. El tamaño de muestra: un enfoque práctico en la investigación clínica pediátrica. Bol Med Hosp Infantil Méx 1995;52(6):381-90.

  6. Greenberg S, Daniels S, Flanders W. Epidemiología médica. 2ª ed. México: El Manual Moderno,1998;pp:149-66.

  7. Norman GR, Streiner DL. Bioestadística. 1ª ed. Madrid: Harcourt- Brace 1998;pp:150-95.

  8. Partonen T. Association of low serum total cholesterol with major depression and suicide. Brit J Psychiatry 1999;175(9):259-62.

  9. Larry FE, Howard IM. Niveles de colesterol sérico y riesgo de suicidio. Epidemiología 2001;12:168-71.

  10. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive Summary of the third report of the National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001;285.

  11. Josefson D. Statins may reduce risk of depression. BMJ 2003;327:467.

  12. Agargun MY. Serum cholesterol concentration, depression, and anxiety. Acta Psychiatr Scand 2002;105:81-83.




2020     |     www.medigraphic.com