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2008, Number 4

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Rev Mex Cir Endoscop 2008; 9 (4)

Importance of the genetic aspects of the obesity in the bariatric surgery

Rivas A, Velázquez D

Language: Spanish
References: 45
Page: 170-176
PDF size: 114.90 Kb.


ABSTRACT

Aim: The aim of this paper is to up date and review the current scientific knowledge about the influence of genetics on obesity and its role on the long-term outcome of obesity surgery. Methods: Analysis and interpretation of recent literature regarding to the different genetic forms of obesity and its implications in the bariatric surgical practice. Results: The identification of genes involved in monogenic, syndromic and polygenic obesity, has improved our understanding about the mechanisms of its development as well as the potential effect of these genes over the outcome of obesity surgery. There are no reports in the literature about the effect of bariatric surgery in monogenic obesity. Surgery has demonstrated discreet results in patients with syndromic obesity in comparison whit normal obese individuals. Regarding polygenic obesity there are some reports of certain single nucleotide polymorphisms (SNPs) associated with a greater weight loss in the postoperative. Conclusions: Genetics have a considerable contribution to the development of different forms of obesity. Similarly, several and different surgical techniques used for weight loss have demonstrated to be effective but variable on their results. For this reason, we strongly recommend surgeons to be aware of the potential applications of this field for better selection and treatment of obese patients.


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