2002, Number 3
Linfoma primario cervical no Hodgkin de células grandes con inmunofenotipo B. Presentación de un caso
Bustos-López HH, Baquera-Heredia J, Robles-Vidal C, Jurado-Jurado M, Rojas-Poceros G, González-Cofrades J, Leger-Vargas M
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Language: Spanish
References: 7
Page: 132-139
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ABSTRACT
Although lymphoma and leukemia frequently infiltrate the uterine corpus, cervix and vagina in cases of advanced disease, these organs are only rarely the initial site of recognized involvement.We present a case of primary Non-Hodgkin cervical lymphoma in a 35 year-old nulliparous woman who assisted at The American Brithis Cowdray Medical Center in Mexico City. She had a first diagnosis of uterine fibroids and abnormal uterine bleeding. Dysmenorrhea and irregular menstrual periods for several months were the presenting complaints. The cervical cytology, vaginal ultrasound, hysterosonography, computed tomography scan, cervical ultrasound guided biopsy, endometrial biopsy, hysteroscopy, laparotomy, histology and immunohistochemistry techniques made feasible the final diagnosis of Non-Hodgkin diffuse cervical lymphoma of large cells with B cells origin, of low risk, stage IE by the Ann Arbor Staging System for extranodal lymphomas. A radical extended hysterectomy was made, plus chemotherapy with cyclophosphamide, adriamycin (doxorubicin), vincristine and prednisone (CHOP) and Mabtera given during six cycles every three weeks, and irradiation to pelvis 50 Gys. She was free of disease after 30 months.
Because of the rarity of primary uterine lymphomas, a standard of treatment has not been defined. Treatments regimens reported have included surgery, radiation and chemotherapy modalities.
The majority of these tumors in the early stages are highly responsive to therapy, it is important for gynecologists to include pelvic lymphoma in the differential diagnosis of gynecologic cancer.
Our awareness alone should help effect a cure in many more patients in the future.
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