2008, Number 3
Rev Biomed 2008; 19 (3)
Antibiotic resistance of Pseudomonas aeruginosa clinical isolates obtained from a university hospital in Lima, Perú
Luján-Roca DA, Ibarra-Trujillo JO, Mamani-Huamán E
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ABSTRACTIntroduction. Pseudomonas aeruginosa is the cause of infections in immunosupressed patients and it is an important nosocomial pathogen.
Objective. To evaluate the antibiotic resistance of P. aeruginosa clinical isolates and to obtain data that can be useful in epidemiological studies.
Materials and methods. Between January and December 2003 a total of 144 Pseudomonas aeruginosa isolates were obtained on culture from patients of the National Hospital Hipólito Unanue (university hospital), Lima, Perú. The antibiotic susceptibility-resistance was evaluated by the disc diffusion Kirby-Bauer method for ceftazidime, cefepime, aztreonam, imipenem, meropenem, amikacin, gentamicin and ciprofloxacin.
Results. The antibiotics that showed higher resistance percentage were: ceftazidime (71%), aztreonam (62%), ciprofloxacin (57%) and gentamicin (55%). The antibiotic that showed better activity was meropenem (73% of sensitive strains).
Conclusions. High antibiotic resistance was found in P. auroginosa isolates obtained from patients of this hospital. The resistance figures were not uniform; therefore, it is suggested to carry out more antibiotic sensitivity-resistance assays to prescribe the appropriate antibiotic treatment as to limit the increase of resistant organisms.