Hernández-Chavarría F, Vega B

Language: English
References: 5
Page: 137-138
PDF size: 20.23 Kb.

Text Extraction

Platelet satellitism is described as an infrequent finding characterized by formation of platelet rosettes around polymorphonuclear (PMN) leucocytes, which are seen in Wright-stained peripheral blood smears prepared from EDTA-anticoagulated blood samples, but not seen when others anticoagulants such as heparin, acid-citrate dextrose, or citrate, are used. The mechanism of this platelet adhesion to PMN is not understood, but there is evidence that autoantibodies directed to the glycoprotein IIb/IIIa complex of the platelet membrane, as well against the neutrophil Fc gama receptor, are involved. It is possible that the epitopes for those antibodies are usually hidden in leukocyte and platelet membranes and that membrane changes induced by EDTA expose them; which would explain why satellitism is observed exclusively in blood anticoagulant with EDTA.

REFERENCES

1. Bizzaro N, Goldschmeding R, von dem Rorne AE. Platelet satellitism is Fc gamma RIII (CD16) receptor-mediated. Am J Clin Pathol 1995; 103:740-4.

2. Crisweil KA, Breider MA, Bleavins MR. EDTA-dependent platelet phagocytosis. A cytochemical, ultrastructural, and functional characterization. Am J Clin Pathol 2001; 115:376-84.

3. Cesca C. Ben-Ezra J. Platelet satellitism as presenting finding in mantle cell lymphoma. Am J Clin Pathol 2001; 115:567-70.

4. Cartín W, Brenes M, Oviedo J, Segura H. Satelitismo plaquetario: Primeros dos casos reportados en Costa Rica. Rev Costarric Cienc Med 2001; 22:65-9.

5. Vega B, Hernández-Chavarría F. Tercer caso de satelitismo plaquetario en Costa Rica: Un fenómeno poco reportado. Rev Cost Cienc Med 2002; 23; 47-51.