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>Journals >Gaceta Médica de México >Year 2008, Issue 6


Márquez MF, Urias-Medina K, Gómez-Flores J, Sobrino A, Sotomayor-González A, González-Hermosillo A, Cárdenas M
Comparación de metoprolol versus clonazepam como tratamiento de primera intención en pacientes con síncope neurocardiogénico
Gac Med Mex 2008; 144 (6)

Language: Español
References: 12
Page: 503-508
PDF: 47.06 Kb.


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ABSTRACT

Objective: We compared the effects of a metoprolol and clonazepam in patients with neurocardiogenic syncope. Methods: We compared the effects of a metoprolol and clonazepam in a prospective, randomised trial in 54 patients. Patients were randomly assigned to metoprolol (starting dose 50 mg bid) or clonazepam (starting dose 0.5 mg qd). We assessed a primary combined endpoint of syncope and pre-syncope on a follow-up of 12 months. Results: The primary combined endpoint of syncope and presyncope occurred in the metoprolol group in 3, 4, and 10% of patients at 3, 6, and 12 months respectively. In the clonazepam group it was no recurrence in the first 6 months, and 5% recurrence at 12 months follow-up (non significant differences between groups). Clinical symptoms commonly associated with neurally mediated syncope were decreased similarly in both treatment groups, in the metoprolol group from 5.2±2.5 to 1.9±2.1 (p ‹ 0.001) and in the clonazepam group from 5.5±2.5 to 1.5±2.2 (p‹0.001). Conclusions: Pharmacological treatment of neurocardiogenic syncope with metoprolol or clonazepam resulted in similar prevention of syncope and presyncope. Both treatments decreased clinical symptoms but complete symptomatic resolution was rarely observed.


Key words: Neurocardiogenic syncope, metoprolol, clonazepam, head tilt-test.


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>Journals >Gaceta Médica de México >Year 2008, Issue 6
 

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