Portillo LML

Language: Spanish
References: 9
Page: 60-63
PDF size: 95.89 Kb.

ABSTRACT

Hemolytic disease of the fetus and newborn is a condition resulting from coating of fetal or newborn red cells with antibodies directed against an antigen of paternal origin present on the fetal cells and absent on the mother’s. It can be classified as: — HDFN by ABO antibodies. — HDNF by Rh antibodies. — HDFN by antibodies from other blood group systems. In all these, serologic evaluation of the mother and the newborn includes determination of ABO and Rh including testing for weak D. In addition, a direct antiglobulin test (DAT) and, if necessary, an elution and phenotyping of the newborn red cells must be performed. The elution procedure selected must be the indicated for the type of antibody suspected. Additional testing with the mother’s specimen includes antibody detection and identification, titer of the antibody identified. If the mother is Rh negative, detection (rosette test) and quantification (Kleihauer-Betke stain) of fetal maternal hemorrhage is necessary to determine the number of doses of Rh immunoglobulin the patient has to receive. There are several techniques available for antibody detection and identification, all with advantages and limitations.

REFERENCES

1. Enfermedad hemolítica del recién nacido. En: Linares J. Inmunohematología y transfusión, principios y procedimientos. 1ra ed. Caracas, Venezuela, 1986: 253.

2. Bracey AW, Moise KJ. Hemolytic disease of the fetus or newborn: treatment and prevention. En: Simon TL, Dzik WH, Stowel CP, Strauss RG. Rossi’s principles of transfusion medicine. 3rd ed. Lippincott Williams & Wilkins, 2002: 428.

3. Perinatal issues in transfusion practice. En: Brecher ME. Technical Manual. 15th ed. Bethesda, MD: AABB; 2005: 535-51.

4. Hemolytic disease of the newborn and fetus. En: Harmening DM. Modern Blood Banking & Transfusion Practices. 5th ed. Philadelphia, PA: FA Davis Company; 2005: 386.

5. Daniels G. Human blood groups. 2nd ed. Oxford: Blackwell Scientific Publications, 2002: 54, 195.

6. Hemolytic disease of the newborn. En: Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific Publications; 1998: 1045, 1067-9.

7. Judd JW. Guidelines for prenatal and perinatal immunohematology. Bethesda, MD: AABB Press; 2005.

8. No value in immune anti-A or anti-B in predicting HDN. En: Mollison PL, Engelfreit CP, Contreras M. Blood Transfusion in Clinical Medicine, 10th ed. Blackwell, Oxford, 1997: 418-424.

9. Inmunología Molecular. Kabul Abbas.