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Órgano Oficial de la Asociación Dental Mexicana

2005, Number 4

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Rev ADM 2005; 62 (4)

Antigen presenting mechanism in pulp tissue

Silva-Herzog FD, Oliva R, Ramos NPC

Language: Spanish
References: 25
Page: 125-131
PDF size: 95.81 Kb.


ABSTRACT

Multimicrobial infection of the dental pulp triggers inflammatory responses because bacteria and noxious substances may gain direct access to the pulp via dentinal tubules. In recent years pulp biology research has provided a deeper insight into the basic mechanisms that govern pulpal defense and repair. Dendritic cells (professional-presenting cells) are both sensors and messengers that form an early-warning network in many tissues and they express class II antigens indicating a capacity for presentation of antigen to T helper cells. This cells are located in the odontoblastic layer as well as the central portions of the pulp tissue and play an important role in capturing the antigens, migrating to the lymph nodes, and presenting them to the lymphocytes. However the presence of T cells in normal dental pulp demonstrate that it is equipped with immunocompetent cells essential for the initiation of immunological responses. The dendritic cells can also interact with nerves and vessels in the pulp. Thus, neuroimmunologic responses of the pulp may be the prime defense reaction in the pulp- dentin organ.


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