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2009, Number 3

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Bioquimia 2009; 34 (3)

Metabolic risk factors for urolithiasis in children

Medina-Escobedo M, Villanueva-Jorge S, Martín-Soberanis G, Medina-Escobedo C, León-Soberanis E, Arcos DA, Correa-Rosado C, Ibarra-Barrera E

Language: Spanish
References: 31
Page: 121-128
PDF size: 64.35 Kb.


ABSTRACT

Background: To identify the metabolic risk factors for the development of urinary lithiasis (UL) in children from Yucatan, Mexico. Methods: Case-control study, which included children, aged ≤ 15 years with and without UL confirmed by ultrasound. Controls did not have any antecedent of either UL or any other disease. Blood and urine samples were collected; indexes for calciuria, uricosuria, phosphaturia, and magnesuria were calculated. Four age- and sex-matched groups were made. Results: Two hundred fifty five children were studied (85 cases and 170 controls). In each group, 56.5% were male. According to age, kids were allocated in four groups. For group I, uricosuria and the H+ urine concentration were greater for cases than for controls (p ‹ 0.05); for groups II, III, and IV, only the uricosuria showed a significant difference (p ‹ 0.05). The average pH was 5.5 for all groups. When comparing the frequencies of metabolic alterations, hypercalcemia, hyperphosphatemia and hyperuricosuria were different (p ‹ 0.05); however, when comparing cases and controls by age group, only shows differences in hyperuricosuria in groups II (p = 0.004) and III (p = 0.04). Conclusion: The hyperuricosuria is the first risk factor for the development of UL in the studied population.


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