Cirugía y Cirujanos

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>Journals >Cirugía y Cirujanos >Year 2009, Issue 5

Zerrweck-López C, Quijano-Orvañanos F, Montañez-Ramírez H, Murillo-Zolezzi A,Toledo-Valdovinos S, Padilla-Longor R
Neuroblastoma en el adulto. Informe de un caso
Cir Cir 2009; 77 (5)

Language: Español
References: 16
Page: 397-401
PDF: 137.84 Kb.

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Background: Neuroblastoma is a common malignancy in infancy but extremely rare in adults. These tumors, commonly found in the abdomen, originate in the sympathetic nervous system. Staging and management are standardized in children and adults, although their prognosis is very different, being more aggressive and with a poorer outcome in the adult.
Clinical case: We present the case of a 31-year-old male with non-specific abdominal pain and constipation. After several studies, a stage III giant retroperitoneal neuroblastoma was diagnosed. We discuss here the evaluation, management and follow-up of the patient, as well as to present a literature review.
Conclusions: Adult neuroblastoma is an unusual disease with an insidious presentation and is usually diagnosed in advanced stages. Unlike its behavior in young patients, in the adult it is more aggressive and with a poor prognosis.

Key words: Neuroblastoma, retroperitoneal tumor.


  1. Woods WG, Gao R, Shuster JJ, Robison LL, Bernstein M, Weitzman S, et al. Screening of infants and mortality due to neuroblastoma. N Engl J Med 2002;340:1041-1046.

  2. Esiashvili N, Goodman M, Ward K, Marcus RB, Johnstone PA. Neuroblastoma in adults: incidence and survival analysis based on SEER data. Pediatr Blood Cancer 2006;49:41-46.

  3. Knudson AG, Strong LC. Mutation and cancer: neuroblastoma and pheochromocytoma. Am J Hum Genet 1972;24:514-532.

  4. Valent A, Le Roux G, Barrois M, Terrier-Lacombe MJ, Valteau-Couanet D, Leon B, et al. MCYN gene overrepresentation detected in primary neuroblastoma tumour cells without amplification. J Pathol 2002;198:495-501.

  5. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985;313:1111-1116.

  6. Schwab M. Amplified MYCN in human neuroblastoma: paradigm for the translation of molecular genetics to clinical oncology. Ann NY Acad Sci 2002;963:63-73.

  7. Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Azar CG, Cantor AB, Brodeur GM. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med 1993;328:847-854.

  8. Lee KL, Ma JF, Shortliffe LD. Neuroblastoma: management, recurrence, and follow up. Urol Clin North Am 2003;30:881-890.

  9. Conte M, Parodi S, De Bernardi B, Milanaccio C, Mazzocco K, Angelini P, et al. Neuroblastoma in adolescents: the Italian experience. Cancer 2006;106:1409-1417.

  10. Alexander F. Neuroblastoma. Urol Clin North Am 2000;27:383-392.

  11. Brodeur GM, Pritchard J, Berthold F, Carlsen NL, Castel V, Castelberry RP, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 1993;11:1466-1477.

  12. Tateishi U, Hasegawa T, Makimoto A, Moriyama N. Adult neuroblastoma: radiologic and clinicopathologic features. J Comput Assist Tomogr 2003;27:321-326.

  13. Ikeda H, Iehara T, Tsuchida Y, Kaneko M, Hata J, Naito H, et al. Experience with International Neuroblastoma Staging System and Pathology Classification. Br J Cancer 2002,86:1110-1116.

  14. Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B, et al. The International Neuroblastoma Pathology Classification (the Shimada System). Cancer 1999;86:364-372.

  15. Katzenstein HM, Cohn SL. Advances in the diagnosis and treatment of neuroblastoma. Curr Opin Oncol 1998;10:43-51.

  16. Pérez CA, Matthay KK, Atkinson JB, Seeger RC, Shimada H, Haase GM, et al. Biologic variables in the outcome of stage I and II neuroblastoma treated with surgery as primary therapy: a Children’s Cancer Group Study. J Clin Oncol 2000;18:18-26.

>Journals >Cirugía y Cirujanos >Year 2009, Issue 5

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