González CA, Alexanderson G, Camacho J, Quiñónez S, Mauricio SP, Hernández-Y-H H, Luengas-E ME

Language: Spanish
References: 74
Page: 314-322
PDF size: 114.22 Kb.

ABSTRACT

The resistance to the insulin and their resultant the hyperinsulinemia, they are factors that through diverse mechanisms, they favor among other alterations to the hypertension and the atherosclerosis. Genetic factors that allow their expression and the manifestation of the illness when coexisting with environmental stimuli participate. The participant mechanisms among other, are the renal retention of sodium, the one stimulates of the activity of the bomb Na+-H+, the decrease of the activity of the Na+-K+ ATPasa dependent of calcium, the increase of the expression of the gene of the endothelin 1, the increase in the synthesis of the factor of growth similar to the insulin 1, the activation of the nice nervous system and the growth and proliferation of the cells of the vascular flat muscle. In all patients, it will be considered the possibility that the resistance to the insulin this involved in the genesis of the illness and to have a wide knowledge of the antihypertensive drugs to select the most convenient, among those that highlight the inhibitors of the ACE inhibitors, the angiotensin II receptor blocker and the calcium antagonists.

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