Quezada LA, Pérez HMA, Rodríguez TJ

Language: Spanish
References: 0
Page: 40-44
PDF size: 281.85 Kb.

ABSTRACT

The bronchodilator effect of dry powder inhaled terbutaline was evaluated in asthmatic children with methacholine-induced acute bronchial obstruction. Eighty eight mild to moderate asthmatic children (52 male, median age 8 years, range 5-17) were enrolled in a double blind study with placebo and methacholine bronchial provocation challenge was performed until a fall in FEV1 ≥ 20% was achieved (PC20). Post methacholine challenge, the children was randomly allocated in two groups to receive terbutaline 0.50 mg or placebo. To evaluate the bronchodilator effect, the increase in FEV1 (DFEV1) at 5 minutes post inhalation was assessed. For statistic analysis Student’s test was used. The groups were comparable for age, basal FEV1, FEV1 variability, methacholine PC20 and FEV1 fall after methacholine challenge. Terbutaline showed a DEV1 of 33.5 ± 4.1% vs. 1.3 ± 0.3% for placebo, with difference highly significant (p ‹ 0.00001). In children between 5 to 7 years old (n=29, terbutaline=14, placebo=15) the effect of inhaled terbutaline was also statistically significant (DFEV1 47.2 ± 10.1 vs 1.4 ± 0.5).In 3 out 88 children cardiac frequency increased over 90 percentile for age (1 with terbutaline, 2 with placebo), without other adverse events. We can conclude that terbutaline inhaled in dry powder reverted efficiently the acute induced bronchial obstruction in mild to moderate asthmatic children compared to placebo, without significant collateral effects.