Ramírez MJA, Garrido GLM, Villalobos CCE, Mason CT, Cervantes BR, Mata RN, Zárate MF, Palacio CL, Munguía VP

Language: Spanish
References: 15
Page: 40-42
PDF size: 205.27 Kb.

ABSTRACT

Ranitidine, an H2 antagonist is a very common drug for the treatment of gastroesophageal reflux (GER) and peptic ulcer diseases, in adults and children. 30% of the drug is metabolized at the liver via P-450-3A4 cytochrome system; 50% is excreted by kidneys. Some reports in the literature have associated the presence of cardiac arrhythmia (bradycardia, A-V blockade) with the use of ranitidine (intravenous) in adults. However it is not clear whether the presence of this abnormal electrocardiogram (EKG) finding can be present with oral use of ranitidine at normal doses for children. Aim: To identify EKG changes in infants taking 8-10 mg/kg/day of ranitidine; a cohort of 30 infants with GER without any previous treatment was studied. An EKG basal and after 30 days with continuous ranitidine administration was performed. QTc interval using the Bazzet´s formula was done; normal values were 440 to < 460 mm/seg. Children with any kind of cardiopathy, prematures, hypokalemia, hypocalcemia, hypomagnesemia were excluded. A decrease tendency in the median ventricular frequency (MVF) and a reduction of the QTc interval without clinical or statistical significance were observed.

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