Guinzberg PR, Díaz CA

Language: English/Spanish
References: 8
Page: 251-254
PDF size: 332.61 Kb.

ABSTRACT

Adenosine and inosine are nucleosides formed during ATP degradation and play an important role on hepatic metabolism regulation. In cells isolated from rat liver, incubated under different experimental conditions, both nucleosides present an ureogenic effect and have the following characteristics: a) This ureogenic effect is present when hepatocytes are incubated with glutamine, alanine or ammonium carbonate, b) The adenosine and inosine regulated metabolic process is dependent upon oxidable substrate, c) When cells are incubated without calcium, an inhibitory effect is observed and d) Adenosine and inosine effect is reverted by glucagon, but not by epinephrine. These described metabolic effects of adenosine and inosine are part of very fine metabolic control system. Its regulation generates the short term response that determines organ functionality. Therefore, it is considered that data presented here is of great physiological importance.

REFERENCES

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