1995, Number 1
Vet Mex 1995; 26 (1)
Efficacy of a hypertonic and hyperoncotic solution, naloxone and oxigen free radicals in the hypovolemic shock treatment in the dog
Gallego MS, Ocampo CL, Portilla BE, Páez ED, Argüero R
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ABSTRACTMany alterations are prouced due to the hypovolemic shock. These alterations contribute to a progressive deterioration on homeostasis, and are influenced by the endotelial cell oedematization. Oxygen free radicals are produced during ischaemia and in major quantity during the reperfusion and by the endorphine liberation. To test the way this shock can be stroken back, hypovolemia was induced in twenty dogs by extracting blood from them. Arterial pressure was kept at 50 mm/Hg for 20 minutes and afterwards, different drugs were administered in order to evaluate their effectiveness on circulatory stability. Animals were divided in 4 groups: Group 0 was administered a hyperoncotic, hypertonic solution (Dextran 60, NaCl 7.5%); Group 1 was administered a hyperoncotic, hypertonic solution plus naloxone, which is an opioid receptor antagonist; Group 2 received a hyperoncotic, hypertonic solution plus dismutase superoxide and catalase enzymes that accept oxygen free radicals, and Group 3 got a combination of all the drugs mentioned above. Another group was submitted to a hypovolemic shock, but was not treated. Results show that hyperonocotic, hypertonic solutions increased arterial pressure and cardiac output. The combination of the hyperoncotic, hypertonic solution plus naloxone produced a higher blood pressure and increased the cardiac output for forty minutes. There was no different therapeutical effect in the group treated with enzymes or cardiac output and arterial pressure recuperations and therefore, the tissue perfusion level in the control group was defective in comparison to the treated groups. It is concluded that the hyperoncotic, hypertonic solution plus naloxone proved to be the most effective combination during a 90 minute period.