Rowensztein H, Berlin V, Scrigni A

Language: Spanish
References: 10
Page: 37-43
PDF size: 116.67 Kb.

ABSTRACT

Background. Craniosynostosis is a congenital malformation caused by premature closure of one or more cranial sutures. The treatment is early surgery for aesthetic reasons and to prevent increased intracranial pressure, neurological developmental disorders and optic atrophy. The aim of the present study was to investigate risk factors for craniosynostosis.
Methods. We designed a case/control study from January 2000-December 2005 in a third-level hospital. Statistical analysis was done using SPSS statistical program.
Results. Included in the study were 59 cases and 177 controls. Males are more commonly affected than females (86%). Diagnosis was made at an average of 5.8 months. Related to type of craniosynostosis, synostosis of the sagittal sutures is the most common form of this malformation. Antibiotics consumption during pregnancy was a risk factor for craniosynostosis (OR =5.13 95% CI 1.57-17.1, P =0.001). Parental occupation and, more specific, cold-storage plant work, was statistically significant (OR =12.8 95% CI 1.37-307, P =0.014. There was no relationship between labor and puerperium and craniosynostosis.
Conclusion. The present study supports an association between antibiotic consumption and parental occupation and development of craniosynostosis.

REFERENCES

1. Portillo S, Konsol O, Pico P. Deformidad craneana. Su importancia en la pediatría general. Arch Argent Pediatr 2004;102:190-202.

2. Jaimovich R, Monges J. Craneosinostosis. En: Fejerman N, Fernández AE. Neurología Pediátrica. Buenos Aires: Ed. Médica Panamericana; 1997.pp.804-807.

3. Ridgway E, Weiner H. Deformidades del cráneo. En: Clínicas Pediátricas de Norteamérica. Neurocirugía. México: Ed. McGraw Hill Interamericana; 2004;2: 337-364.

4. Zeiger J, Beaty T, Hetmanski J, Wang H, Scott A, Kasch L, et al. Genetic and environmental risk factors for sagittal craniosynostosis. J Craniofac Surg 2002;13: 602-606.

5. Kallén K. Maternal smoking and craniosynostosis. Teratology 1999;60:146-150.

6. Di Rocco F, Arnaud E, Renier D. Evolution in the frequency of nonsyndromic craniosynostosis. J Neurosurg Pediatr 2009;4:21-25.

7. Alderman BW, Bradley CM, Greene C. Increased risk of craniosynostosis with maternal cigarette smoking during pregnancy. Teratology 1994;50:13-18.

8. Bradley C, Alderman BW, Williams MA, Checkoway H, Fernbach SK, Greene C, et al. Parental occupations as risk factors for craniosynostosis in offspring. Epidemiology 1995;6:306-310.

9. Alderman BW, Zamudio S, Baron AE. Increased risk of craniosynostosis with higher antenatal maternal altitude. Int J Epidemiol 1995;24:420-426.

10. Reefhuis J, Honein MA, Shaw GM, Romitti PA. Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997. Pediatrics 2003;111:1163-1166.