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Alergia, Asma e Inmunología Pediátricas

Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría
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2008, Number 2

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Alerg Asma Inmunol Pediatr 2008; 17 (2)

Allergy to latex

Huerta LJ
Full text How to cite this article

Language: Spanish
References: 9
Page: 65-69
PDF size: 278.41 Kb.


Key words:

Latex, irritant dermatitis, retarded hypersensitivity, immediate hypersensitivity, T lymphocytes, atopic people.

ABSTRACT

The use of natural rubber (or latex) in a number of objects related to medical activities is an increasing problem. Latex is compound of cis-1,4-polyisoprene, an organic polymer that supplies strength and elasticity. It also contains a great number of carbohydrates, lipids, nucleic acids, and highly allergenic proteins. During the decades of 1980 and 1990, the increase in the demand of latex for the manufacture of gloves and other objects produced an increase of allergenic reactions among patients and medical staffs. Sensitivity may occur after contact with the skin or the mucous membranes, with the peritoneum during certain surgeries and after inhaling sprayed particles containing latex on surface.
There are three basic classical syndromes associated with this type of allergy: 1) Irritant dermatitis; 2) Retarded hypersensitivity reaction (of type IV); and 3) Immediate hypersensitivity (of type I). The spectrum of clinical manifestations goes from localized and generalized urticaria (nettle rash or hives) to rhinitis, hypotension, and complete anaphylaxis, which may place the patient’s life at danger.
Allergy to latex is present in only the 1.5% of the general population, with an augmented prevalence among atopic people. This percentage rises up from the 2 to the 17% in sanitary professionals and up to the 10% in latex industry workers. Some statistical data have shown a 14% of incidence among emergency service workers and up to the 14% in emergency pediatrics service doctors. Usually, patients presenting bifid spine are genetically predisposed to the usual latex antigen, as well as those patients suffering from brain paralysis, mental retardation or tetraplegia (quadriplegia).
Among the hospital articles manufactured from latex, there are gloves, Foley-type vesical sounds (or urinary catheters), endotracheal tubes, systems for serum dosage (or drug delivery systems), adhesive tapes, ambu, bandages, drainers, disposable trochars, etc. Among the usual materials, we may find: balloons, preservatives, synthetic sponges, pacifiers, suckers, plugs, etc. All of these products should be avoided for people presenting high sensitivity. In health centers, equivalent products not containing latex should be preferred. Fortunately, hospital are increasingly adopting dustless, non-allergenic, powder-free polymer gloves.


REFERENCES

  1. Nutter AF. Contact urticaria to rubber. Br J Dermatol 1979; 101: 597-8.

  2. Slater JE. Rubber anaphylaxis. N Eng J Med 1989; 320: 1126-30.

  3. Leynadier F, Pecquet C, Dry J. Anaphylaxis to latex during surgery. Anesthesia 1989; 44: 547-50.

  4. Gerber AC, Jorg W, Zbiden S, Serger RA, Dangel PH. Severe intraoperative anaphylaxis to surgical gloves: Latex allergy, an unfamiliar condition. Anesthesiology 1989; 71: 800-2.

  5. Sethna NF, Sockin SM, Holzman RS, Slater JE. Latex anaphylaxis in a child with a history of multiple anesthetic drug allergies. Anesthesiology 1992; 77: 372-5.

  6. Morales C, Basomba A, Carreira J, Sastre A. Anaphylaxis produced by rubber glove contact: Case reports and inmunological identification of de antigens involved. Clin Exp Allergy 1989; 19: 425-30.

  7. Slater JE, Mostello LA, Shaer C, Honsinger RW. Type I hypersensitivity to rubber. Anm Allergy 1990; 65: 411-4.

  8. Sussan GL, Tarlo S, Dolovich J. The spectrum of IgE mediated responses to latex. JAMA 1991; 265: 2844-7.

  9. Wrangso K, Wablberg JE, Alxelsson GK. IgE mediated allergy to natural rubber in 30 patients with contact urticaria. Contact Dermatitis 1988; 19: 264-71.




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Alerg Asma Inmunol Pediatr. 2008;17