Rubio GAF, Vargas AG, Lozano NJJ , Rodríguez LL, Ramos BLM

Language: Spanish
References: 13
Page: 329-333
PDF size: 222.94 Kb.

ABSTRACT

Background: Both hypertension and type-2 diabetes are cardiovascular risk factors that produce endothelial dysfunction, which in turn decreases nitric oxide production and promotes albuminuria.
Objective: To compare endothelial function in diabetic, hypertensive and normotensive patients, with health patients, and to correlate it with albuminuria degree.
Patients and method: We included 80 type-2 diabetic patients (40 normotensive and 40 hypertensive), and 40 normotensive healthy patients, in whom endothelial function was measured using Griess method for detection of circulating nitrite levels, and 24-hrs albuminuria. Statistical analysis was performed with ANOVA, and correlations with Spearman coefficient of correlation.
Results: There was not meaningful difference between hypertensive (3.4 ± 0.1 Mmol/L) and normotensive diabetic patients (3.6 ± 0.3 Mmol/L). However, diabetic patients had significantly increased levels of nitrites when compared with healthy patients (5.7 ± 0. Mmol/L 4, p ‹ 0.005). When nitrite values were correlated with 24-hrs albuminuria, we found that nitrites had an inverse correlation with albuminuria in both normotensive (R = - 0.2) and hypertensive (R = - 0.7) diabetic patients.
Conclusions: Diabetic patients showed higher endothelial dysfunction than healthy patients, but it does not worse hypertension. This endothelial dysfunction had a correlation with 24-hrs albuminuria in diabetic patients, both normotensive and hypertensive.

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