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Colegio de Medicina Interna de México.
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2008, Number 5

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Med Int Mex 2008; 24 (5)

Agranulocytosis wi th atypical react ive plasmocytosis induced by methimazole in a patient with hypertiroidism

León MF, Mateos THN, Caballero CR, Suárez OR, García VMA
Full text How to cite this article

Language: Spanish
References: 9
Page: 357-360
PDF size: 212.02 Kb.


Key words:

methimazole, hyperthyroidism, agranulocytosis, reactive plasmocytosis.

ABSTRACT

Methimazole is the most common drug used to treat hyperthyroidism in Mexico. An unusual secondary effect is agranulocytosis, however reactive plasmocytosis is even more rare. We report a case in a young patient and possible mechanisms are discussed.


REFERENCES

  1. Breier DV, Rendo P, Gonzalez J, Shilton G, et al. Massive plasmocytosis due to methimazole-induced bone marrow toxicity. Am J Hematol 2001;67:259-61.

  2. McKenzie SB. Hepatología clínica. 2ª ed. México: El Manual Moderno, 2002;pp:337.

  3. Godwin JE, Braden CD. Neutropenia. eMedicine [available online: http://www.emedicine.com/MED/topic1640.htm] Updated august 9, 2006.

  4. Ruiz-Gil W, Tokumura TC, Ruiz-Rodríguez C. Severe reactive plasmocytosis and agranulocytosis associated with methimazol. Rev Med Hered 2005;16(2):158.

  5. Rocca NJ, Valdivia CH, Arbañil HH, Loayza UN. Agranulocitosis inducida por metimazol: a propósito de tres casos. Rev Peru Endocr Metabol 2002;5(1-2):79-83.

  6. Hodak SP, Huang C, Clarke D, Burman HD, et al. Intravenous methimazole in the treatment of refractory hyperthyroidism. Thyroid 2006;16(7):691-5.

  7. Beauchesne MF, Shalansky SJ. Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. Pharmacotherapy 1999;19(3):299- 305.

  8. Tajiri J, Noguchi S. Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? Thyroid 2005;15(3):292-7.

  9. Andres E, Maloisel F. Idiosyncratic drug-induced agranulocytosis or acute neutropenia. Curr Opin Hematol 2008;15(1):15- 21.




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Med Int Mex. 2008;24