2002, Number 4
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ABSTRACTObjective: To determine whether acute intake of alcohol increases risk for development of acute complications such as diabetic ketoacidosis (DK), hyperglycemic hyperosmolar nonketotic syndrome (HHNS), and hypoglycemia. Study design: Cases and controls in three urban Mexican hospitals. Methods: We carried out the study in Hospitals 1, 26, and 47 of the Instituto Mexicano del Seguro Social (IMSS). Included were all patients who were treated at the emergency service with diagnosis of diabetic ketoacidosis, hypoglycemia, and hyperglycemic hyperosmolar nonketotic state. Diabetic patients who entered the emergency room for reasons other than acute complication of diabetes were considered controls. In both groups we investigated alcohol intake for the past 2 weeks, kind of alcohol and amount, as well as clinical manifestations when subjects entered emergency rooms (ethylic intoxi-cation, ethylic suppression syndrome, or with no symptom). Results: We studied 61 cases and 65 controls, found 11 patients in each group who accepted to have consumed alcohol with a mean of 3 ± 2.7 days acute intake of alcohol, with 2.4 ± 2.7 days suspended alcohol intake. There were 18 patients with DK, 18 with HHNS, 13 with mixed state (DK and HHNS), and 12 with hypoglycemia; 86.9 % had type 2 diabetes mellitus, 59 % accepted not eating an appropriate diet, 24.6 % failed to take their medicine, and infections were present in 31 cases. There was no significant difference (p › 0.05). However, in the group and controls who accepted acute intake of alcohol, we found a significant difference only at time of evolution of diabetes; in this case with group 8.3 ± 5.2 years and control 16.1 ± 3.3 years, there was a significant difference (p ‹ 0.05). Conclusions: We failed to demonstrate that acute intake of alcohol increased risk of development of acute complications of diabetes mellitus.
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